(6R,7S)-7-((1R,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-6-(tert-butyl-dimethyl-silanyloxy)-1,1,1-trifluoro-2-trifluoromethyl-octan-2-ol

Base Information

Chemical Name:(6R,7S)-7-((1R,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-6-(tert-butyl-dimethyl-silanyloxy)-1,1,1-trifluoro-2-trifluoromethyl-octan-2-ol
CAS No.:143101-79-5
Molecular Formula:C₃₂H₅₀F₆O₃Si
Molecular Weight:624.823
Hs Code.:

(6R,7S)-7-((1R,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-6-(tert-butyl-dimethyl-silanyloxy)-1,1,1-trifluoro-2-trifluoromethyl-octan-2-ol

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Chemical Property of (6R,7S)-7-((1R,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-6-(tert-butyl-dimethyl-silanyloxy)-1,1,1-trifluoro-2-trifluoromethyl-octan-2-ol

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Technology Process of (6R,7S)-7-((1R,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-6-(tert-butyl-dimethyl-silanyloxy)-1,1,1-trifluoro-2-trifluoromethyl-octan-2-ol

There total 24 articles about (6R,7S)-7-((1R,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-6-(tert-butyl-dimethyl-silanyloxy)-1,1,1-trifluoro-2-trifluoromethyl-octan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143101-71-7,147674-53-1
(S)-2-((1R,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-propionaldehyde

: 143101-79-5,143167-91-3,147731-39-3
(6S,7S)-7-((1R,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-6-(tert-butyl-dimethyl-silanyloxy)-1,1,1-trifluoro-2-trifluoromethyl-octan-2-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 39 percent / diethyl ether; tetrahydrofuran / 0 °C

2: pyridine / Ambient temperature

3: 35 h / 150 °C

4: K₂CO₃ / methanol / Ambient temperature

5: Collins reagent

6: 96 percent / H₂ / 5percent Pd/C / methanol / 1 h / 760 Torr / Ambient temperature

7: 67 percent / NaBH₄ / ethanol / Ambient temperature

8: 2,6-lutidine / CH₂Cl₂ / Ambient temperature

With pyridine; 2,6-dimethylpyridine; sodium tetrahydroborate; Collins oxidation agent; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1248/cpb.40.1346

Reference yield:

: 143101-71-7,147674-53-1
(S)-2-((1R,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-propionaldehyde

: 143101-79-5,143167-91-3,147731-39-3
(6R,7S)-7-((1R,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-6-(tert-butyl-dimethyl-silanyloxy)-1,1,1-trifluoro-2-trifluoromethyl-octan-2-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 39 percent / diethyl ether; tetrahydrofuran / 0 °C

2: pyridine / Ambient temperature

3: 35 h / 150 °C

4: K₂CO₃ / methanol / Ambient temperature

5: Collins reagent

6: 96 percent / H₂ / 5percent Pd/C / methanol / 1 h / 760 Torr / Ambient temperature

7: 23 percent / NaBH₄ / ethanol / Ambient temperature

8: 2,6-lutidine / CH₂Cl₂ / Ambient temperature

With pyridine; 2,6-dimethylpyridine; sodium tetrahydroborate; Collins oxidation agent; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1248/cpb.40.1346

Reference yield:

: 143101-72-8,143167-94-6,147731-33-7
(2S,3S)-2-((1R,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-hex-5-en-3-ol

: 143101-79-5,143167-91-3,147731-39-3
(6S,7S)-7-((1R,4S,7aR)-4-Benzyloxy-7a-methyl-octahydro-inden-1-yl)-6-(tert-butyl-dimethyl-silanyloxy)-1,1,1-trifluoro-2-trifluoromethyl-octan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / pyridine / Ambient temperature

2: 74 percent / 35 h / 150 °C

3: 92 percent / K₂CO₃ / methanol / Ambient temperature

4: 96 percent / Collins reagent

5: 96 percent / H₂ / 5percent Pd/C / methanol / 1 h / 760 Torr / Ambient temperature

6: 67 percent / NaBH₄ / ethanol / Ambient temperature

7: 2,6-lutidine / CH₂Cl₂ / Ambient temperature

With pyridine; 2,6-dimethylpyridine; sodium tetrahydroborate; Collins oxidation agent; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; ethanol; dichloromethane;
DOI:10.1248/cpb.40.1346