(2R,4S)-isopropyl 4-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate.

Base Information

Chemical Name:(2R,4S)-isopropyl 4-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate.
CAS No.:867011-80-1
Molecular Formula:C₂₆H₂₆F₉N₇O₂
Molecular Weight:639.524
Hs Code.:

(2R,4S)-isopropyl 4-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate.

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Chemical Property of (2R,4S)-isopropyl 4-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate.

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (2R,4S)-isopropyl 4-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate.

There total 9 articles about (2R,4S)-isopropyl 4-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate. which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₆F₃N₃O

: 867011-80-1
(2R,4S)-isopropyl 4-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate.

: 867011-79-8
C₂₆H₂₆F₉N₇O₂

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / 0 - 20 °C

2: hydrogenchloride / water / 80 °C

3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

5: sodium azide; triethylamine / toluene / 110 °C

6: potassium carbonate / acetonitrile

7: Chiralpak AD / Resolution of racemate

With pyridine; hydrogenchloride; sodium azide; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2012.03.075

Reference yield:

: C₁₇H₂₂F₃N₃O₃

: 867011-80-1
(2R,4S)-isopropyl 4-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate.

: 867011-79-8
C₂₆H₂₆F₉N₇O₂

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / water / 80 °C

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

4: sodium azide; triethylamine / toluene / 110 °C

5: potassium carbonate / acetonitrile

6: Chiralpak AD / Resolution of racemate

With hydrogenchloride; sodium azide; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2012.03.075

Reference yield:

: C₂₅H₂₃F₉N₄O₂

: 867011-80-1
(2R,4S)-isopropyl 4-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate.

: 867011-79-8
C₂₆H₂₆F₉N₇O₂

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide; triethylamine / toluene / 110 °C

2: potassium carbonate / acetonitrile

3: Chiralpak AD / Resolution of racemate

With sodium azide; potassium carbonate; triethylamine; In toluene; acetonitrile;
DOI:10.1016/j.bmcl.2012.03.075