2-(2,2-dichloroacetamido)ethyl ((2S,3R)-3-Hydroxy-4-(N-((S)-2-methylbutyl)benzo[d]thiazole-6-sulfonamido)-1-phenylbutan-2-yl)carbamate

Base Information

• Chemical Name: 2-(2,2-dichloroacetamido)ethyl ((2S,3R)-3-Hydroxy-4-(N-((S)-2-methylbutyl)benzo[d]thiazole-6-sulfonamido)-1-phenylbutan-2-yl)carbamate
• CAS No.: 1066866-79-2
• Molecular Formula: C₂₇H₃₄Cl₂N₄O₆S₂
• Molecular Weight: 645.628
• Mol file: 1066866-79-2.mol

Synonyms:

Chemical Property of 2-(2,2-dichloroacetamido)ethyl ((2S,3R)-3-Hydroxy-4-(N-((S)-2-methylbutyl)benzo[d]thiazole-6-sulfonamido)-1-phenylbutan-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,2-dichloroacetamido)ethyl ((2S,3R)-3-Hydroxy-4-(N-((S)-2-methylbutyl)benzo[d]thiazole-6-sulfonamido)-1-phenylbutan-2-yl)carbamate

There total 2 articles about 2-(2,2-dichloroacetamido)ethyl ((2S,3R)-3-Hydroxy-4-(N-((S)-2-methylbutyl)benzo[d]thiazole-6-sulfonamido)-1-phenylbutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H29N3O3S2 (1026701-90-5) + 2-(2,2-dichloroacetamido)ethyl (4-nitrophenyl)carbonate (1386394-46-2) → 2-(2,2-dichloroacetamido)ethyl ((2S,3R)-3-Hydroxy-4-(N-((S)-2-methylbutyl)benzo[d]thiazole-6-sulfonamido)-1-phenylbutan-2-yl)carbamate (1066866-79-2)

Guidance literature:

C₂₂H₂₉N₃O₃S₂; With tertiary amine; In tetrahydrofuran; at 0 ℃; for 0.166667h;

2-(2,2-dichloroacetamido)ethyl (4-nitrophenyl)carbonate; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jm300238h

Reference yield:

tert-butyl ((2S,3R)-3-hydroxy-4-(N-((2S)-2-methylbutyl)benzo[d]thiazole-6-sulfonamido)-1-phenylbutan-2-yl)carbamate (1026701-54-1) → 2-(2,2-dichloroacetamido)ethyl ((2S,3R)-3-Hydroxy-4-(N-((S)-2-methylbutyl)benzo[d]thiazole-6-sulfonamido)-1-phenylbutan-2-yl)carbamate (1066866-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C

2.1: tertiary amine / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0 - 20 °C

With trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm300238h

upstream raw materials:

tert-butyl ((2S,3R)-3-hydroxy-4-(N-((2S)-2-methylbutyl)benzo[d]thiazole-6-sulfonamido)-1-phenylbutan-2-yl)carbamate

C₂₂H₂₉N₃O₃S₂

2-(2,2-dichloroacetamido)ethyl (4-nitrophenyl)carbonate