Morpholin-4-yl-phosphonic acid mono-((2R,3S,4R,5R)-3-hydroxy-4-(3-methoxy-benzoylamino)-5-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl) ester

Base Information

• Chemical Name: Morpholin-4-yl-phosphonic acid mono-((2R,3S,4R,5R)-3-hydroxy-4-(3-methoxy-benzoylamino)-5-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl) ester
• CAS No.: 332079-09-1
• Molecular Formula: C₃₃H₃₆N₇O₈P
• Molecular Weight: 689.665
• Mol file: 332079-09-1.mol

Synonyms:

Chemical Property of Morpholin-4-yl-phosphonic acid mono-((2R,3S,4R,5R)-3-hydroxy-4-(3-methoxy-benzoylamino)-5-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Morpholin-4-yl-phosphonic acid mono-((2R,3S,4R,5R)-3-hydroxy-4-(3-methoxy-benzoylamino)-5-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl) ester

There total 4 articles about Morpholin-4-yl-phosphonic acid mono-((2R,3S,4R,5R)-3-hydroxy-4-(3-methoxy-benzoylamino)-5-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N6-(1-naphthalenemethyl)-2'-deoxy-2'-(3-methoxybenzamido)adenosine (239100-12-0) → Morpholin-4-yl-phosphonic acid mono-((2R,3S,4R,5R)-3-hydroxy-4-(3-methoxy-benzoylamino)-5-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl) ester (332079-09-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 5-ethylthiotetrazole / acetonitrile / 0.5 h / -10 °C

2: t-BuOOH / acetonitrile / 0.33 h / 20 °C

3: NH₄OH / methanol / 17 h / 20 °C

4: DCC / 2-methyl-propan-2-ol; H₂O / 16 h / Heating

With tert.-butylhydroperoxide; ammonium hydroxide; 5-(ethylthio)-1H-tetrazole; dicyclohexyl-carbodiimide; In methanol; water; acetonitrile; tert-butyl alcohol;

DOI:10.1016/S0960-894X(00)00608-9

Reference yield:

Phosphoric acid bis-(2-cyano-ethyl) ester (2R,3S,4R,5R)-3-hydroxy-4-(3-methoxy-benzoylamino)-5-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl ester → Morpholin-4-yl-phosphonic acid mono-((2R,3S,4R,5R)-3-hydroxy-4-(3-methoxy-benzoylamino)-5-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl) ester (332079-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₄OH / methanol / 17 h / 20 °C

2: DCC / 2-methyl-propan-2-ol; H₂O / 16 h / Heating

With ammonium hydroxide; dicyclohexyl-carbodiimide; In methanol; water; tert-butyl alcohol;

DOI:10.1016/S0960-894X(00)00608-9

Reference yield:

Phosphorous acid bis-(2-cyano-ethyl) ester (2R,3S,4R,5R)-3-hydroxy-4-(3-methoxy-benzoylamino)-5-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl ester → Morpholin-4-yl-phosphonic acid mono-((2R,3S,4R,5R)-3-hydroxy-4-(3-methoxy-benzoylamino)-5-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl) ester (332079-09-1)

Guidance literature:

Multi-step reaction with 3 steps

1: t-BuOOH / acetonitrile / 0.33 h / 20 °C

2: NH₄OH / methanol / 17 h / 20 °C

3: DCC / 2-methyl-propan-2-ol; H₂O / 16 h / Heating

With tert.-butylhydroperoxide; ammonium hydroxide; dicyclohexyl-carbodiimide; In methanol; water; acetonitrile; tert-butyl alcohol;

DOI:10.1016/S0960-894X(00)00608-9

upstream raw materials:

morpholine

Phosphoric acid mono-((2R,3S,4R,5R)-3-hydroxy-4-(3-methoxy-benzoylamino)-5-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl) ester

N⁶-(1-naphthalenemethyl)-2'-deoxy-2'-(3-methoxybenzamido)adenosine