Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-isobutyrylamino-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Chemical Name:Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-isobutyrylamino-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
CAS No.:138836-87-0
Molecular Formula:C₄₅H₅₆N₇O₈P
Molecular Weight:853.956
Hs Code.:

Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-isobutyrylamino-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Chemical Property of Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-isobutyrylamino-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Technology Process of Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-isobutyrylamino-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

There total 9 articles about Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-isobutyrylamino-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 138856-93-6
N-<1-<5-O--2-deoxy-β-D-ribofuranosyl>-3-methyl-7-oxo-1H-pyrazolo<4,3-d>pyrimidin-5-yl>-2-methylpropanamide

: 138836-87-0,138836-96-1
Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-isobutyrylamino-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h;
DOI:10.1021/ja00030a050

Reference yield:

: 28668-07-7
ethyl 3-methyl-4-nitro-1H-pyrazole-5-carboxylate

: 138836-87-0,138836-96-1
Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-isobutyrylamino-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 46 percent / NaH / acetonitrile / 1 h

2: 88 percent / NH₃, CH₃OH / 24 h / 120 °C

3: 90 percent / H₂₂ / 10percent Pd/C / ethanol; H₂O / 5 h / 2585.7 Torr / Ambient temperature

4: 85 percent / pyridine / 0.75 h / Heating

5: 1.) conc. NH₄OH, 30percent aq. H₂O₂, 2.) NH₃ / 1.) 0 deg C, 40 min, 2.) 120 deg C, 12 h

6: 1.) Me₃SiCl, pyridine / 1.) 0 deg C, 30 min, 2.) RT, 3 h

7: 75 percent / pyridine / 4 °C

8: 83 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 1 h

With pyridine; methanol; ammonium hydroxide; chloro-trimethyl-silane; ammonia; dihydrogen peroxide; sodium hydride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In pyridine; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ja00030a050

Reference yield:

: 4330-21-6
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

: 138836-87-0,138836-96-1
Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-isobutyrylamino-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 46 percent / NaH / acetonitrile / 1 h

2: 88 percent / NH₃, CH₃OH / 24 h / 120 °C

3: 90 percent / H₂₂ / 10percent Pd/C / ethanol; H₂O / 5 h / 2585.7 Torr / Ambient temperature

4: 85 percent / pyridine / 0.75 h / Heating

5: 1.) conc. NH₄OH, 30percent aq. H₂O₂, 2.) NH₃ / 1.) 0 deg C, 40 min, 2.) 120 deg C, 12 h

6: 1.) Me₃SiCl, pyridine / 1.) 0 deg C, 30 min, 2.) RT, 3 h

7: 75 percent / pyridine / 4 °C

8: 83 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 1 h

With pyridine; methanol; ammonium hydroxide; chloro-trimethyl-silane; ammonia; dihydrogen peroxide; sodium hydride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In pyridine; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ja00030a050