(E)-N'-[7-(4-chlorophenyl)-4-cyano-3-dimethylamino-2-(4-nitrophenyl)-2H-pyrazolo[3,4-c]pyridin-5-yl]-N,N-dimethylformamidine

Base Information

• Chemical Name: (E)-N'-[7-(4-chlorophenyl)-4-cyano-3-dimethylamino-2-(4-nitrophenyl)-2H-pyrazolo[3,4-c]pyridin-5-yl]-N,N-dimethylformamidine
• CAS No.: 1445138-01-1
• Molecular Formula: C₂₄H₂₁ClN₈O₂
• Molecular Weight: 488.936
• Mol file: 1445138-01-1.mol

Synonyms:

Chemical Property of (E)-N'-[7-(4-chlorophenyl)-4-cyano-3-dimethylamino-2-(4-nitrophenyl)-2H-pyrazolo[3,4-c]pyridin-5-yl]-N,N-dimethylformamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N'-[7-(4-chlorophenyl)-4-cyano-3-dimethylamino-2-(4-nitrophenyl)-2H-pyrazolo[3,4-c]pyridin-5-yl]-N,N-dimethylformamidine

There total 2 articles about (E)-N'-[7-(4-chlorophenyl)-4-cyano-3-dimethylamino-2-(4-nitrophenyl)-2H-pyrazolo[3,4-c]pyridin-5-yl]-N,N-dimethylformamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-amino-6-(4-chlorophenyl)-5-(4-nitrophenylazo)nicotinonitrile (1445137-96-1) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → (E)-N'-[7-(4-chlorophenyl)-4-cyano-3-dimethylamino-2-(4-nitrophenyl)-2H-pyrazolo[3,4-c]pyridin-5-yl]-N,N-dimethylformamidine (1445138-01-1)

Guidance literature:

In toluene; for 6h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2013.05.040

Reference yield:

C15H10ClN3O4 (1445137-89-2) → (E)-N'-[7-(4-chlorophenyl)-4-cyano-3-dimethylamino-2-(4-nitrophenyl)-2H-pyrazolo[3,4-c]pyridin-5-yl]-N,N-dimethylformamidine (1445138-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate; acetic acid / Reflux

2: toluene / 6 h / Inert atmosphere; Reflux

With ammonium acetate; acetic acid; In toluene;

DOI:10.1016/j.tet.2013.05.040

Reference yield: 73.0%

(E)-N'-[7-(4-chlorophenyl)-4-cyano-3-dimethylamino-2-(4-nitrophenyl)-2H-pyrazolo[3,4-c]pyridin-5-yl]-N,N-dimethylformamidine (1445138-01-1) → 4-(4-chlorophenyl)-2-(4-nitrophenyl)-1-dimethylamino-2H-pyrazolo[4',3':4,5]pyrido-[2,3-d]pyrimidine-9-amine (1445138-06-6)

Guidance literature:

With ammonium acetate; acetic acid; for 3h; Reflux;

DOI:10.1016/j.tet.2013.05.040

upstream raw materials:

2-amino-6-(4-chlorophenyl)-5-(4-nitrophenylazo)nicotinonitrile

N,N-dimethyl-formamide dimethyl acetal

C₁₅H₁₀ClN₃O₄

Downstream raw materials:

4-(4-chlorophenyl)-2-(4-nitrophenyl)-1-dimethylamino-2H-pyrazolo[4',3':4,5]pyrido-[2,3-d]pyrimidine-9-amine