N-<(1S,2S)-1,3-dicyclohexyl-1-hydroxy-2-propyl>-8-ethenyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazine-3-acetamide

Base Information

Chemical Name:N-<(1S,2S)-1,3-dicyclohexyl-1-hydroxy-2-propyl>-8-ethenyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazine-3-acetamide
CAS No.:134829-21-3
Molecular Formula:C₃₀H₃₉N₅O₂
Molecular Weight:501.672
Hs Code.:

Synonyms:

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Chemical Property of N-<(1S,2S)-1,3-dicyclohexyl-1-hydroxy-2-propyl>-8-ethenyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazine-3-acetamide

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Technology Process of N-<(1S,2S)-1,3-dicyclohexyl-1-hydroxy-2-propyl>-8-ethenyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazine-3-acetamide

There total 9 articles about N-<(1S,2S)-1,3-dicyclohexyl-1-hydroxy-2-propyl>-8-ethenyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazine-3-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 134829-22-4
N-<(1S,2S)-1,3-dicyclohexyl-1-hydroxy-2-propyl>-8-(2-methylsulphinylethyl)-6-phenyl-1,2,4-triazolo<4,3-a>pyrazine-3-acetamide

: 134829-21-3
N-<(1S,2S)-1,3-dicyclohexyl-1-hydroxy-2-propyl>-8-ethenyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazine-3-acetamide

Guidance literature:: In toluene; for 1h; Heating;

Reference yield:

: 1074-12-0
phenylglyoxal hydrate

: 134829-21-3
N-<(1S,2S)-1,3-dicyclohexyl-1-hydroxy-2-propyl>-8-ethenyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazine-3-acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: 41 percent / 12.5 M aq. NaOH / methanol / 1.) -40 deg C, 2 h, 2.) RT, 1 h

2: 99 percent / COCl₂ / tetrahydrofuran; toluene / 4 h / Heating

3: 92 percent / 55percent NH₂NH₂*H₂O / butan-1-ol / 4 h / Heating

4: 87 percent / ethyl acetate / 1 h / 0 °C

5: 74 percent / p-TsOH*H₂O / toluene / 3 h / Heating

6: 85 percent / 1 M aq. NaOH / dioxane / 1 h / Ambient temperature

7: 80 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, 1-hydroxybenzotriazole, Et₃N / dimethylformamide / Ambient temperature

8: 95 percent / 85percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 1 h / 0 °C

9: 67 percent / toluene / 1 h / Heating

With sodium hydroxide; benzotriazol-1-ol; toluene-4-sulfonic acid; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; butan-1-ol;

Reference yield:

: 132407-93-3
3-(2-methylthioethyl)-5-phenyl-2(1H)-pyrazinone

: 134829-21-3
N-<(1S,2S)-1,3-dicyclohexyl-1-hydroxy-2-propyl>-8-ethenyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazine-3-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / COCl₂ / tetrahydrofuran; toluene / 4 h / Heating

2: 92 percent / 55percent NH₂NH₂*H₂O / butan-1-ol / 4 h / Heating

3: 87 percent / ethyl acetate / 1 h / 0 °C

4: 74 percent / p-TsOH*H₂O / toluene / 3 h / Heating

5: 85 percent / 1 M aq. NaOH / dioxane / 1 h / Ambient temperature

6: 80 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, 1-hydroxybenzotriazole, Et₃N / dimethylformamide / Ambient temperature

7: 95 percent / 85percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 1 h / 0 °C

8: 67 percent / toluene / 1 h / Heating

With sodium hydroxide; benzotriazol-1-ol; toluene-4-sulfonic acid; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; butan-1-ol;