N-(5-{[(2-{[amino(imino)methyl]amino}ethyl)amino]carbonyl}-1-methyl-1H-pyrrol-3-yl)-4-({4-[(E)-2-(3-methoxyphenyl)ethenyl]benzoyl}amino)-1-methyl-1H-pyrrole-2-carboxamide

Base Information

Chemical Name:N-(5-{[(2-{[amino(imino)methyl]amino}ethyl)amino]carbonyl}-1-methyl-1H-pyrrol-3-yl)-4-({4-[(E)-2-(3-methoxyphenyl)ethenyl]benzoyl}amino)-1-methyl-1H-pyrrole-2-carboxamide
CAS No.:1407491-98-8
Molecular Formula:C₃₁H₃₄N₈O₄
Molecular Weight:582.662
Hs Code.:

N-(5-{[(2-{[amino(imino)methyl]amino}ethyl)amino]carbonyl}-1-methyl-1H-pyrrol-3-yl)-4-({4-[(E)-2-(3-methoxyphenyl)ethenyl]benzoyl}amino)-1-methyl-1H-pyrrole-2-carboxamide

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Chemical Property of N-(5-{[(2-{[amino(imino)methyl]amino}ethyl)amino]carbonyl}-1-methyl-1H-pyrrol-3-yl)-4-({4-[(E)-2-(3-methoxyphenyl)ethenyl]benzoyl}amino)-1-methyl-1H-pyrrole-2-carboxamide

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Technology Process of N-(5-{[(2-{[amino(imino)methyl]amino}ethyl)amino]carbonyl}-1-methyl-1H-pyrrol-3-yl)-4-({4-[(E)-2-(3-methoxyphenyl)ethenyl]benzoyl}amino)-1-methyl-1H-pyrrole-2-carboxamide

There total 7 articles about N-(5-{[(2-{[amino(imino)methyl]amino}ethyl)amino]carbonyl}-1-methyl-1H-pyrrol-3-yl)-4-({4-[(E)-2-(3-methoxyphenyl)ethenyl]benzoyl}amino)-1-methyl-1H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1407491-76-2
C₃₀H₃₂N₆O₄

: methyl imidothiocarbamate hydroiodide

: 1407491-98-8
N-(5-{[(2-{[amino(imino)methyl]amino}ethyl)amino]carbonyl}-1-methyl-1H-pyrrol-3-yl)-4-({4-[(E)-2-(3-methoxyphenyl)ethenyl]benzoyl}amino)-1-methyl-1H-pyrrole-2-carboxamide

Guidance literature:: With potassium carbonate; In ethanol; for 48h; Reflux;
DOI:10.1016/j.ejmech.2012.08.013

Reference yield:

: 1108614-51-2
2-{[(1-methyl-4-nitro-1H-pyrrol-2-yl)carbonyl]amino}ethyl acetate

: 1407491-98-8
N-(5-{[(2-{[amino(imino)methyl]amino}ethyl)amino]carbonyl}-1-methyl-1H-pyrrol-3-yl)-4-({4-[(E)-2-(3-methoxyphenyl)ethenyl]benzoyl}amino)-1-methyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 3 h

2: 4-methyl-morpholine / dichloromethane; N,N-dimethyl-formamide

3: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 0 °C

4: N,N-dimethyl-formamide / 72 h / 55 °C

5: trifluoroacetic acid / dichloromethane / 0.5 h / Reflux

6: potassium carbonate / ethanol / 48 h / Reflux

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; potassium carbonate; trifluoroacetic acid; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.08.013

Reference yield:

: 28494-51-1
1-methyl-4-nitro-1H-pyrrole-2-carbonyl chloride

: 1407491-98-8
N-(5-{[(2-{[amino(imino)methyl]amino}ethyl)amino]carbonyl}-1-methyl-1H-pyrrol-3-yl)-4-({4-[(E)-2-(3-methoxyphenyl)ethenyl]benzoyl}amino)-1-methyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methyl-morpholine / dichloromethane; N,N-dimethyl-formamide

2: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 0 °C

3: N,N-dimethyl-formamide / 72 h / 55 °C

4: trifluoroacetic acid / dichloromethane / 0.5 h / Reflux

5: potassium carbonate / ethanol / 48 h / Reflux

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; potassium carbonate; trifluoroacetic acid; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.08.013