Technology Process of (S)-3-methyl-2-(8-(5-phenyl-1,2,4-oxadiazol-3-yl)dibenzo[b,d]furan-3-sulfonamido)butanoic acid
There total 13 articles about (S)-3-methyl-2-(8-(5-phenyl-1,2,4-oxadiazol-3-yl)dibenzo[b,d]furan-3-sulfonamido)butanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 12 steps
1: nitric acid; trifluoroacetic acid / 2 h / 20 °C
2: palladium on activated charcoal; hydrogen / methanol
3: hydrogenchloride; sodium nitrite / acetic acid
4: sulfur dioxide; copper dichloride / acetic acid / 20 h / 0 - 20 °C
5: chlorine; acetic acid / water / 8 h / 0 - 20 °C
6: bromine / acetic acid / 6 h / 76 °C
7: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
8: tetrakis(triphenylphosphine) palladium(0) / 1-methyl-pyrrolidin-2-one / 1 h / 120 °C / Microwave irradiation
9: hydroxylamine; triethylamine / 6 h / 20 °C
10: dichloromethane / 2 h / 0 °C
11: dimethyl sulfoxide / 1 h / 90 °C
12: water; lithium hydroxide / tetrahydrofuran / 24 h
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); palladium on activated charcoal; sulfur dioxide; water; hydrogen; hydroxylamine; bromine; nitric acid; chlorine; acetic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper dichloride; lithium hydroxide; sodium nitrite;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; acetic acid;
DOI:10.1016/j.bmcl.2011.11.046
- Guidance literature:
-
Multi-step reaction with 3 steps
1: dichloromethane / 2 h / 0 °C
2: dimethyl sulfoxide / 1 h / 90 °C
3: water; lithium hydroxide / tetrahydrofuran / 24 h
With
water; dimethyl sulfoxide; lithium hydroxide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2011.11.046
- Guidance literature:
-
Multi-step reaction with 9 steps
1: sulfur dioxide; copper dichloride / acetic acid / 20 h / 0 - 20 °C
2: chlorine; acetic acid / water / 8 h / 0 - 20 °C
3: bromine / acetic acid / 6 h / 76 °C
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
5: tetrakis(triphenylphosphine) palladium(0) / 1-methyl-pyrrolidin-2-one / 1 h / 120 °C / Microwave irradiation
6: hydroxylamine; triethylamine / 6 h / 20 °C
7: dichloromethane / 2 h / 0 °C
8: dimethyl sulfoxide / 1 h / 90 °C
9: water; lithium hydroxide / tetrahydrofuran / 24 h
With
tetrakis(triphenylphosphine) palladium(0); sulfur dioxide; water; hydroxylamine; bromine; chlorine; acetic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; copper dichloride; lithium hydroxide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetic acid;
DOI:10.1016/j.bmcl.2011.11.046
