Technology Process of 2-{2-[bis(phenylsulfanyl)methyl]phenyl}acetaldehyde
There total 6 articles about 2-{2-[bis(phenylsulfanyl)methyl]phenyl}acetaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
tetrahydrofuran;
at 66 ℃;
for 3h;
DOI:10.1039/c3ob40115d
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: bromine / tetrachloromethane / Irradiation
2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C
2.2: 12 h
3.1: diisobutylaluminium hydride / dichloromethane; toluene / 2.33 h / -78 °C / Cooling with ice
4.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 12 h / 0 °C / Cooling with ice
5.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -78 °C
5.2: 12 h / Cooling with ice
6.1: hydrogenchloride / tetrahydrofuran / 3 h / 66 °C
With
hydrogenchloride; bromine; sodium hexamethyldisilazane; sulfur trioxide pyridine complex; sodium hydride; diisobutylaluminium hydride; triethylamine;
In
tetrahydrofuran; tetrachloromethane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
5.1: |Wittig Olefination;
DOI:10.1039/c3ob40115d
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 12 h / 0 °C / Cooling with ice
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -78 °C
2.2: 12 h / Cooling with ice
3.1: hydrogenchloride / tetrahydrofuran / 3 h / 66 °C
With
hydrogenchloride; sodium hexamethyldisilazane; sulfur trioxide pyridine complex; triethylamine;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
2.1: |Wittig Olefination;
DOI:10.1039/c3ob40115d
