4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo [4,5-h][1,6]naphthyridin-5-oxo)-N-((R)-1-phenylethyl)benzamide

Base Information

Chemical Name:4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo [4,5-h][1,6]naphthyridin-5-oxo)-N-((R)-1-phenylethyl)benzamide
CAS No.:1422434-22-7
Molecular Formula:C₃₇H₃₄Cl₂N₆O₃
Molecular Weight:681.621
Hs Code.:

4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo [4,5-h][1,6]naphthyridin-5-oxo)-N-((R)-1-phenylethyl)benzamide

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Chemical Property of 4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo [4,5-h][1,6]naphthyridin-5-oxo)-N-((R)-1-phenylethyl)benzamide

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Technology Process of 4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo [4,5-h][1,6]naphthyridin-5-oxo)-N-((R)-1-phenylethyl)benzamide

There total 9 articles about 4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo [4,5-h][1,6]naphthyridin-5-oxo)-N-((R)-1-phenylethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1422434-22-7
4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo [4,5-h][1,6]naphthyridin-5-oxo)-N-((R)-1-phenylethyl)benzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane;

Reference yield:

: C₄₂H₄₂Cl₂N₆O₅

: 1422434-22-7
4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo [4,5-h][1,6]naphthyridin-5-oxo)-N-((R)-1-phenylethyl)benzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1039/c2ob26710a

Reference yield:

: 1223081-81-9
5-bromo-8-(((1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl)amino)-1,6-naphthyridine-7-carboxylic acid

: 1422434-22-7
4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo [4,5-h][1,6]naphthyridin-5-oxo)-N-((R)-1-phenylethyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 90 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 110 °C

4: lithium hydroxide; water / tetrahydrofuran / 20 °C

5: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

6: trifluoroacetic acid / dichloromethane / 20 °C

With diphenyl phosphoryl azide; water; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 3: |Williamson Ether Synthesis;
DOI:10.1039/c2ob26710a