Benzenepropanoic acid, 4-(1H-1,2,4-triazol-1-yl)-, hydrazide

Base Information

• Chemical Name: Benzenepropanoic acid, 4-(1H-1,2,4-triazol-1-yl)-, hydrazide
• CAS No.: 139311-96-9
• Molecular Formula: C11H13N5O
• Molecular Weight: 231.257
• Mol file: 139311-96-9.mol

Synonyms:

Chemical Property of Benzenepropanoic acid, 4-(1H-1,2,4-triazol-1-yl)-, hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepropanoic acid, 4-(1H-1,2,4-triazol-1-yl)-, hydrazide

There total 6 articles about Benzenepropanoic acid, 4-(1H-1,2,4-triazol-1-yl)-, hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-(4-[1,2,4]Triazol-1-yl-phenyl)-propionic acid ethyl ester (143426-73-7) → 3-(4-[1,2,4]Triazol-1-yl-phenyl)-propionic acid hydrazide (139311-96-9)

Guidance literature:

With hydrazine hydrate; In ethanol; at 100 ℃; for 3h;

DOI:10.1016/0223-5234(92)90005-L

Reference yield:

4-fluorobenzoic acid ethyl ester (451-46-7) → 3-(4-[1,2,4]Triazol-1-yl-phenyl)-propionic acid hydrazide (139311-96-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 48 percent / NaH / dimethylsulfoxide / 18 h / 100 °C

2: 77 percent / NaBH₄, CaCl₂ / tetrahydrofuran / Ambient temperature

3: 49 percent / pyridinium chlorochromate (PCC) / CH₂Cl₂ / 1.5 h / Ambient temperature

4: 92 percent / K₂CO₃ / ethanol / 2 h / 70 °C

5: 93 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h / 45 °C / 3040 Torr

6: 71 percent / NH₂NH₂*H₂O / ethanol / 3 h / 100 °C

With sodium tetrahydroborate; hydrogen; sodium hydride; potassium carbonate; hydrazine hydrate; pyridinium chlorochromate; calcium chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;

DOI:10.1016/0223-5234(92)90005-L

Reference yield:

ethyl 4-(1,2,4-triazol-1-yl)benzoate (143426-48-6) → 3-(4-[1,2,4]Triazol-1-yl-phenyl)-propionic acid hydrazide (139311-96-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 77 percent / NaBH₄, CaCl₂ / tetrahydrofuran / Ambient temperature

2: 49 percent / pyridinium chlorochromate (PCC) / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 92 percent / K₂CO₃ / ethanol / 2 h / 70 °C

4: 93 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h / 45 °C / 3040 Torr

5: 71 percent / NH₂NH₂*H₂O / ethanol / 3 h / 100 °C

With sodium tetrahydroborate; hydrogen; potassium carbonate; hydrazine hydrate; pyridinium chlorochromate; calcium chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;

DOI:10.1016/0223-5234(92)90005-L

upstream raw materials:

3-(4-[1,2,4]Triazol-1-yl-phenyl)-propionic acid ethyl ester

4-fluorobenzoic acid ethyl ester

[4-(1H-1,2,4-triazol-1-yl)phenyl]methanol

ethyl 4-(1,2,4-triazol-1-yl)benzoate