Technology Process of exo-3-p-nitrobenzyl-endo-3-phenyl-3-phosphoniabicyclo<3.2.1>octane bromide
There total 4 articles about exo-3-p-nitrobenzyl-endo-3-phenyl-3-phosphoniabicyclo<3.2.1>octane bromide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 85 percent / anhydrous LiBr / acetone / 96 h / Heating
2: 67 percent / toluene / 1.) 15 h, reflux, 2.) 15 h, reflux
3: 20 percent NaOH / H2O / 5 h / Heating
4: 1.) phenylsilane, 2.) 20 percent NaOH / 1.) 45-55 deg C, 12 h
5: 70 percent / diethyl ether / 48 h
With
sodium hydroxide; phenylsilane; lithium bromide;
In
diethyl ether; water; acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 67 percent / toluene / 1.) 15 h, reflux, 2.) 15 h, reflux
2: 20 percent NaOH / H2O / 5 h / Heating
3: 1.) phenylsilane, 2.) 20 percent NaOH / 1.) 45-55 deg C, 12 h
4: 70 percent / diethyl ether / 48 h
With
sodium hydroxide; phenylsilane;
In
diethyl ether; water; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 20 percent NaOH / H2O / 5 h / Heating
2: 1.) phenylsilane, 2.) 20 percent NaOH / 1.) 45-55 deg C, 12 h
3: 70 percent / diethyl ether / 48 h
With
sodium hydroxide; phenylsilane;
In
diethyl ether; water;
