{2-deoxy-3-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl}-N-{2-[4,7,10-tris(2,2,2-trifluoroacetyl)-1,4,7,10-tetraazacyclododecan-1-yl]ethyl}acetamide

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Chemical Name:{2-deoxy-3-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl}-N-{2-[4,7,10-tris(2,2,2-trifluoroacetyl)-1,4,7,10-tetraazacyclododecan-1-yl]ethyl}acetamide
CAS No.:1337923-66-6
Molecular Formula:C₅₃H₆₇F₉N₇O₁₀P
Molecular Weight:1164.12
Hs Code.:

{2-deoxy-3-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl}-N-{2-[4,7,10-tris(2,2,2-trifluoroacetyl)-1,4,7,10-tetraazacyclododecan-1-yl]ethyl}acetamide

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Chemical Property of {2-deoxy-3-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl}-N-{2-[4,7,10-tris(2,2,2-trifluoroacetyl)-1,4,7,10-tetraazacyclododecan-1-yl]ethyl}acetamide

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Technology Process of {2-deoxy-3-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl}-N-{2-[4,7,10-tris(2,2,2-trifluoroacetyl)-1,4,7,10-tetraazacyclododecan-1-yl]ethyl}acetamide

There total 3 articles about {2-deoxy-3-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl}-N-{2-[4,7,10-tris(2,2,2-trifluoroacetyl)-1,4,7,10-tetraazacyclododecan-1-yl]ethyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: pyridinium [2-deoxy-5-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]acetate

: 1337923-66-6
{2-deoxy-3-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl}-N-{2-[4,7,10-tris(2,2,2-trifluoroacetyl)-1,4,7,10-tetraazacyclododecan-1-yl]ethyl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 °C

2: triethylamine / methanol / 75 h / 20 °C

3: triethylamine / acetonitrile / 1 h / Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; acetonitrile;
DOI:10.1080/15257770.2011.583809

Reference yield:

: [2-deoxy-5-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]-N-[2-(1,4,7,10-tetraazacyclododecan-1-yl)ethyl]acetamide

: 1337923-66-6
{2-deoxy-3-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl}-N-{2-[4,7,10-tris(2,2,2-trifluoroacetyl)-1,4,7,10-tetraazacyclododecan-1-yl]ethyl}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / methanol / 75 h / 20 °C

2: triethylamine / acetonitrile / 1 h / Inert atmosphere

With triethylamine; In methanol; acetonitrile;
DOI:10.1080/15257770.2011.583809

Reference yield:

: 197784-37-5
ethyl [2-deoxy-5-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]acetate

: 1337923-66-6
{2-deoxy-3-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl}-N-{2-[4,7,10-tris(2,2,2-trifluoroacetyl)-1,4,7,10-tetraazacyclododecan-1-yl]ethyl}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; potassium hydroxide / 1,4-dioxane

1.2: Dowex resin in HPy(+) form / 2 h / 20 °C

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 °C

3.1: triethylamine / methanol / 75 h / 20 °C

4.1: triethylamine / acetonitrile / 1 h / Inert atmosphere

With water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In 1,4-dioxane; methanol; acetonitrile;
DOI:10.1080/15257770.2011.583809