dezocine hydrobromide

Base Information

• Chemical Name: dezocine hydrobromide
• CAS No.: 42013-66-1
• Molecular Formula: BrH*C₁₆H₂₃NO
• Molecular Weight: 326.277
• Mol file: 42013-66-1.mol

Synonyms:

Chemical Property of dezocine hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dezocine hydrobromide

There total 6 articles about dezocine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,9S,15S)-4-Methoxy-1-methyl-tricyclo[7.5.1.02,7]pentadeca-2,4,6-trien-15-ylamine; compound with (2S,3S)-2,3-dihydroxy-succinic acid (42264-66-4,42471-99-8,50897-84-2,50897-85-3,58383-83-8,58406-57-8) → dezocine hydrobromide (42013-66-1,42264-28-8,57236-36-9,58383-80-5,60505-64-8)

Guidance literature:

With hydrogen bromide; In water; for 2h; Inert atmosphere; Reflux; Large scale;

Reference yield:

4-Methoxy-1-methyl-tricyclo[7.5.1.02,7]pentadeca-2,4,6-trien-15-one oxime (50666-38-1,131434-60-1) → dezocine hydrobromide (42013-66-1,42264-28-8,57236-36-9,58383-80-5,60505-64-8)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen; ammonium hydroxide / ethanol / 20 h / 45 °C / 1650.17 - 26252.6 Torr / Autoclave; Large scale

2: methanol / 0.25 h / Large scale

3: ammonium hydroxide / water; ethyl acetate / 0.25 h / pH 9

4: methanol / 0.25 h / Large scale

5: hydrogen bromide / water / 2 h / Inert atmosphere; Reflux; Large scale

With ammonium hydroxide; hydrogen bromide; hydrogen; In methanol; ethanol; water; ethyl acetate;

Reference yield:

13-amino-5,6,7,8,9,10,11,12-octahydro-3-methoxy-5-methyl-5,11-methanobenzocyclodecene → dezocine hydrobromide (42013-66-1,42264-28-8,57236-36-9,58383-80-5,60505-64-8)

Guidance literature:

Multi-step reaction with 4 steps

1: methanol / 0.25 h / Large scale

2: ammonium hydroxide / water; ethyl acetate / 0.25 h / pH 9

3: methanol / 0.25 h / Large scale

4: hydrogen bromide / water / 2 h / Inert atmosphere; Reflux; Large scale

With ammonium hydroxide; hydrogen bromide; In methanol; water; ethyl acetate;

upstream raw materials:

4-Methoxy-1-methyl-tricyclo[7.5.1.0^2,7]pentadeca-2,4,6-trien-15-one oxime

(1R,9S,15S)-4-Methoxy-1-methyl-tricyclo[7.5.1.0^2,7]pentadeca-2,4,6-trien-15-ylamine; compound with (2S,3S)-2,3-dihydroxy-succinic acid

Downstream raw materials:

dezocine

Refernces