Technology Process of ethyl (2E)-3-(5α-tert-butyldimethylsilyloxy-3β-(3,3-ethylenedioxybutyl)-2,2,4α-trimethylcyclohexan-1α-yl)acrylate
There total 11 articles about ethyl (2E)-3-(5α-tert-butyldimethylsilyloxy-3β-(3,3-ethylenedioxybutyl)-2,2,4α-trimethylcyclohexan-1α-yl)acrylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 63.9 percent / AcONa, hydrogen / 10percent Pd-C / ethyl acetate / 6 h / 73550.8 Torr / Ambient temperature
2: 84.1 percent / NaBH4 / methanol / 1 h / -11 - -9 °C
3: 100 percent / imidazole / dimethylformamide / 13 h / Ambient temperature
4: 1.5 g / LiAlH4 / diethyl ether / 0.5 h / 0 °C
5: 1.35 g / AcONa*3H2O, PCC / CH2Cl2 / 2.5 h / Ambient temperature
6: toluene / 16 h / 100 °C
With
1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; sodium acetate; pyridinium chlorochromate;
palladium on activated charcoal;
In
methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.36.4722
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 88.4 percent / aq. 16percent titanium trichloride, AcONH4, MeONa / H2O; methanol / 0.33 h / Ambient temperature
2: 85.5 percent / Jones reagent / acetone / 0.5 h / 5 °C
3: 470 mg / K2CO3 / acetone / Heating
4: p-toluenesulfonic acid, Zeolite A-3 / benzene / 1 h / Heating
5: 63.9 percent / AcONa, hydrogen / 10percent Pd-C / ethyl acetate / 6 h / 73550.8 Torr / Ambient temperature
6: 84.1 percent / NaBH4 / methanol / 1 h / -11 - -9 °C
7: 100 percent / imidazole / dimethylformamide / 13 h / Ambient temperature
8: 1.5 g / LiAlH4 / diethyl ether / 0.5 h / 0 °C
9: 1.35 g / AcONa*3H2O, PCC / CH2Cl2 / 2.5 h / Ambient temperature
10: toluene / 16 h / 100 °C
With
1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; jones reagent; titanium(III) chloride; Zeolite A-3; ammonium acetate; hydrogen; sodium methylate; sodium acetate; potassium carbonate; toluene-4-sulfonic acid; pyridinium chlorochromate;
palladium on activated charcoal;
In
methanol; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; benzene;
DOI:10.1248/cpb.36.4722
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 470 mg / K2CO3 / acetone / Heating
2: p-toluenesulfonic acid, Zeolite A-3 / benzene / 1 h / Heating
3: 63.9 percent / AcONa, hydrogen / 10percent Pd-C / ethyl acetate / 6 h / 73550.8 Torr / Ambient temperature
4: 84.1 percent / NaBH4 / methanol / 1 h / -11 - -9 °C
5: 100 percent / imidazole / dimethylformamide / 13 h / Ambient temperature
6: 1.5 g / LiAlH4 / diethyl ether / 0.5 h / 0 °C
7: 1.35 g / AcONa*3H2O, PCC / CH2Cl2 / 2.5 h / Ambient temperature
8: toluene / 16 h / 100 °C
With
1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; Zeolite A-3; hydrogen; sodium acetate; potassium carbonate; toluene-4-sulfonic acid; pyridinium chlorochromate;
palladium on activated charcoal;
In
methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; benzene;
DOI:10.1248/cpb.36.4722
