InterMedine N-Oxide

Base Information

• Chemical Name: InterMedine N-Oxide
• CAS No.: 95462-14-9
• Molecular Formula: C₁₅H₂₅NO₆
• Molecular Weight: 315.367
• Mol file: 95462-14-9.mol

Synonyms:

Chemical Property of InterMedine N-Oxide

Chemical Property:

• Storage Temp.: -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Intermedine N-oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Intermedine N-oxide is a pyrrolizidine alkaloid that is isolated from Cerinthe glabra, a flower plant that grows in alpine areas. Intermedine N-oxide is also a potential anticancer agent.

Technology Process of InterMedine N-Oxide

There total 12 articles about InterMedine N-Oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

intermedine (10285-06-0,26131-12-4) → intermedine N-oxide (95462-14-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In acetone;

DOI:10.1016/S0040-4039(00)94265-5

Reference yield:

(2S,3R)-2,3-dihydroxy-2-(1-methylethyl)butyric acid (23944-48-1) → intermedine N-oxide (95462-14-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / concd hydrochloric acid / Ambient temperature

2: 1.) DCC, DMAP; 2.) 0.6 M HCl / 1.) toluene, r.t., 3 d; 2.) r.t., 8 h

3: 98 percent / MCPBA / acetone / 1 h / Ambient temperature

With hydrogenchloride; dmap; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In acetone;

DOI:10.1246/bcsj.60.4107

Reference yield:

2-O-benzyl-(+)-trachelanthic acid (109305-76-2) → intermedine N-oxide (95462-14-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / hydrogen / 10 percent Pd/C / methanol / 3 h / Ambient temperature

2: 90 percent / concd hydrochloric acid / Ambient temperature

3: 1.) DCC, DMAP; 2.) 0.6 M HCl / 1.) toluene, r.t., 3 d; 2.) r.t., 8 h

4: 98 percent / MCPBA / acetone / 1 h / Ambient temperature

With hydrogenchloride; dmap; hydrogen; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; acetone;

DOI:10.1246/bcsj.60.4107

upstream raw materials:

intermedine

(2S,3R)-2,3-dihydroxy-2-(1-methylethyl)butyric acid

2-O-benzyl-(+)-trachelanthic acid

4(S)-(1-methylethyl)-2,2,5(R)-trimethyl-1,3-dioxolane-4-carboxylic acid

Downstream raw materials:

lycopsamine A

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