dimethyl-2,2 diphenyl-3,5 oxo-5 pentane nitrile

Base Information

• Chemical Name: dimethyl-2,2 diphenyl-3,5 oxo-5 pentane nitrile
• CAS No.: 31787-33-4
• Molecular Formula: C₁₉H₁₉NO
• Molecular Weight: 277.366
• Mol file: 31787-33-4.mol

Synonyms:

Chemical Property of dimethyl-2,2 diphenyl-3,5 oxo-5 pentane nitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl-2,2 diphenyl-3,5 oxo-5 pentane nitrile

There total 5 articles about dimethyl-2,2 diphenyl-3,5 oxo-5 pentane nitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

4-benzoyl-2,2-dimethyl-3-phenylbutyronitrile O-carboxymethyloxime (78414-83-2) → 4-cyano-4-methyl-3-phenylvalerophenone azine (78414-89-8) + dimethyl-2,2 diphenyl-3,5 oxo-5 pentane nitrile (31787-33-4)

Guidance literature:

With potassium peroxomonosulphate; In sodium hydroxide; water; for 0.0833333h; Heating;

DOI:10.1039/P19810001712

Reference yield:

5-[(Z)-Hydroxyimino]-2,2-dimethyl-3,5-diphenyl-pentanenitrile → dimethyl-2,2 diphenyl-3,5 oxo-5 pentane nitrile (31787-33-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / aq. ethanol / 1 h / Heating

2: 31 percent / potassium persulphate / aq. NaOH; H₂O / 0.08 h / Heating

With sodium hydroxide; potassium peroxomonosulphate; In sodium hydroxide; ethanol; water;

DOI:10.1039/P19810001712

Reference yield:

Isobutyronitrile (78-82-0) + benzalacetophenone (94-41-7) → dimethyl-2,2 diphenyl-3,5 oxo-5 pentane nitrile (31787-33-4)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) hexane, THF, -74 deg C -> 0 deg C, 2.) -74 deg C -> room temperature;

DOI:10.1039/P19810001712

upstream raw materials:

2-bromo-2-methyl-propionitrile

benzalacetophenone

Isobutyronitrile

4-benzoyl-2,2-dimethyl-3-phenylbutyronitrile O-carboxymethyloxime

Downstream raw materials:

4-benzoyl-2,2-dimethyl-3-phenylbutyronitrile O-carboxymethyloxime

4-cyano-4-methyl-3-phenylvalerophenone azine

Refernces

• 1、 Gorrichon-Guigon, L.,Hammerer, S.. "ADDITIONS REGIOSELECTIVES D'IMINES ET D'HYDRAZONES METALLEES AUX α-ENONES". . p. 631 - 640. Retrieved 2007/10/02.