(S)-6-Benzyl-4-hydroxy-4-((R)-methoxy-phenyl-methyl)-[1,3]oxazinan-2-one

Base Information

Chemical Name:(S)-6-Benzyl-4-hydroxy-4-((R)-methoxy-phenyl-methyl)-[1,3]oxazinan-2-one
CAS No.:101639-88-7
Molecular Formula:C₁₉H₂₁NO₄
Molecular Weight:327.38
Hs Code.:

Synonyms:

Suppliers and Price of (S)-6-Benzyl-4-hydroxy-4-((R)-methoxy-phenyl-methyl)-[1,3]oxazinan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-6-Benzyl-4-hydroxy-4-((R)-methoxy-phenyl-methyl)-[1,3]oxazinan-2-one

Chemical Property:

Purity/Quality:: 99% ，98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (S)-6-Benzyl-4-hydroxy-4-((R)-methoxy-phenyl-methyl)-[1,3]oxazinan-2-one

There total 13 articles about (S)-6-Benzyl-4-hydroxy-4-((R)-methoxy-phenyl-methyl)-[1,3]oxazinan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32174-46-2
methyl (R)-(-)-2-methoxy-2-phenylacetate

: 101639-88-7,101693-99-6
(S)-6-Benzyl-4-hydroxy-4-((R)-methoxy-phenyl-methyl)-[1,3]oxazinan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: DIBAL / CH₂Cl₂; hexane / 1.) -78 deg C, 40 min, 2.) -78 to -30 deg C, 2 h

2: 91 percent / hydroxylamine hydrochloride, NaOH / ethanol; H₂O / 1.5 h / 0 °C

3: 5.34 g / Et₃N, 5.25percent Chlorox^R / CH₂Cl₂ / 2 h / 0 °C

4: H₂ / Raney Ni / methanol; H₂O; acetic acid

5: 1) pyridine, 2) NH₃ / 1) CH₂Cl₂, 0 deg C, 30 min, 2) MeOH, -78 to 20 deg C, 1 h

With pyridine; sodium hydroxide; sodium hypochlorite; hydroxylamine hydrochloride; ammonia; hydrogen; diisobutylaluminium hydride; triethylamine; nickel; In methanol; ethanol; hexane; dichloromethane; water; acetic acid;
DOI:10.1016/S0040-4020(01)96704-3

Reference yield:

: 72538-27-3
(-)-(R)-2-methoxy-2-phenylacetaldehyde

: 101639-88-7,101693-99-6
(S)-6-Benzyl-4-hydroxy-4-((R)-methoxy-phenyl-methyl)-[1,3]oxazinan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / hydroxylamine hydrochloride, NaOH / ethanol; H₂O / 1.5 h / 0 °C

2: 5.34 g / Et₃N, 5.25percent Chlorox^R / CH₂Cl₂ / 2 h / 0 °C

3: H₂ / Raney Ni / methanol; H₂O; acetic acid

4: 1) pyridine, 2) NH₃ / 1) CH₂Cl₂, 0 deg C, 30 min, 2) MeOH, -78 to 20 deg C, 1 h

With pyridine; sodium hydroxide; sodium hypochlorite; hydroxylamine hydrochloride; ammonia; hydrogen; triethylamine; nickel; In methanol; ethanol; dichloromethane; water; acetic acid;
DOI:10.1016/S0040-4020(01)96704-3

Reference yield:

: 611-71-2
(R)-Mandelic Acid

: 101639-88-7,101693-99-6
(S)-6-Benzyl-4-hydroxy-4-((R)-methoxy-phenyl-methyl)-[1,3]oxazinan-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: conc H₂SO₄ / 2.5 h / Heating

2: Ag₂O / dimethylformamide / 22 h / Ambient temperature

3: DIBAL / CH₂Cl₂; hexane / 1.) -78 deg C, 40 min, 2.) -78 to -30 deg C, 2 h

4: 91 percent / hydroxylamine hydrochloride, NaOH / ethanol; H₂O / 1.5 h / 0 °C

5: 5.34 g / Et₃N, 5.25percent Chlorox^R / CH₂Cl₂ / 2 h / 0 °C

6: H₂ / Raney Ni / methanol; H₂O; acetic acid

7: 1) pyridine, 2) NH₃ / 1) CH₂Cl₂, 0 deg C, 30 min, 2) MeOH, -78 to 20 deg C, 1 h

With pyridine; sodium hydroxide; sodium hypochlorite; sulfuric acid; hydroxylamine hydrochloride; ammonia; hydrogen; diisobutylaluminium hydride; triethylamine; silver(l) oxide; nickel; In methanol; ethanol; hexane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)96704-3