L-697818

Base Information

• Chemical Name: L-697818
• CAS No.: 133216-45-2
• Molecular Formula: C₂₅H₃₈N₂O₂
• Molecular Weight: 398.589
• Mol file: 133216-45-2.mol

Synonyms:

Chemical Property of L-697818

Chemical Property:

• Boiling Point: 621.5±55.0 °C(Predicted)
• Density: 1.13±0.1 g/cm3(Predicted)

Purity/Quality:

HPLC ≥ 98% ^*data from raw suppliers

N-Des(1,1-dimethylethyl)N-CyclohexylFinasteride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-Des(1,1-dimethylethyl) N-Cyclohexyl Finasteride is an impurity of Finasteride (F342000); an inhibitor of 5α-reductase which is the enzyme that converts testosterone to the more potent androgen 5α-dihydrotestosterone.Also an antialopecia agent.

Technology Process of L-697818

There total 5 articles about L-697818 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H40N2O2 → L-697818 (133216-45-2)

Guidance literature:

With N,O-bis(trimethylsilyl)trifluoroacetamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In toluene; at 90 - 95 ℃;

DOI:10.14233/ajchem.2014.16603

Reference yield:

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester (73671-92-8) → L-697818 (133216-45-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 50 - 55 °C

2: benzotriazol-1-ol; dicyclohexyl-carbodiimide

3: N,O-bis(trimethylsilyl)trifluoroacetamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 90 - 95 °C

With N,O-bis(trimethylsilyl)trifluoroacetamide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; In methanol; toluene;

DOI:10.14233/ajchem.2014.16603

Reference yield:

3-oxo-4-aza-5α-androstane-17β-carboxylic acid (103335-55-3,1430804-94-6) → L-697818 (133216-45-2)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; dicyclohexyl-carbodiimide

2: N,O-bis(trimethylsilyl)trifluoroacetamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 90 - 95 °C

With N,O-bis(trimethylsilyl)trifluoroacetamide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In toluene;

DOI:10.14233/ajchem.2014.16603

upstream raw materials:

(4aR,4bS,6aS,7S,9aS,9bS,11aR)-7-(Imidazole-1-carbonyl)-4a,6a-dimethyl-1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-indeno[5,4-f]quinolin-2-one

3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylic acid

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

3-oxo-4-aza-5α-androstane-17β-carboxylic acid

Refernces

• 1、 Bhattacharya, A.,Williams, J.M.,Amato, J.S.,Dolling, U.-H.,Grabowski, E.J.J.. "Acylimidazolides as Versatile Synthetic Intermediates for the Preparation of Sterically Congested Amides and Ketones: A Practical Synthesis of Proscar". . p. 2683 - 2690. Retrieved 2007/10/02.