(8S,9S,14S,17R)-10,13-Dimethyl-17-[(1R,4R)-1-methyl-4-((1R,2R)-2-methyl-cyclopropyl)-pentyl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

Base Information

• Chemical Name: (8S,9S,14S,17R)-10,13-Dimethyl-17-[(1R,4R)-1-methyl-4-((1R,2R)-2-methyl-cyclopropyl)-pentyl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS No.: 91279-15-1
• Molecular Formula: C₂₉H₄₈O
• Molecular Weight: 412.7

Synonyms:

Chemical Property of (8S,9S,14S,17R)-10,13-Dimethyl-17-[(1R,4R)-1-methyl-4-((1R,2R)-2-methyl-cyclopropyl)-pentyl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (8S,9S,14S,17R)-10,13-Dimethyl-17-[(1R,4R)-1-methyl-4-((1R,2R)-2-methyl-cyclopropyl)-pentyl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

There total 7 articles about (8S,9S,14S,17R)-10,13-Dimethyl-17-[(1R,4R)-1-methyl-4-((1R,2R)-2-methyl-cyclopropyl)-pentyl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-(4S,5R,8R)-4-Hydroxy-8-((3bS,6R,8aS,8bS,10aR)-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-5-methyl-non-6-en-2-ynoic acid isopropyl ester (99477-96-0) → (8S,9S,14S,17R)-10,13-Dimethyl-17-[(1R,4R)-1-methyl-4-((1R,2R)-2-methyl-cyclopropyl)-pentyl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol (67314-15-2,91279-13-9,91279-14-0,91279-15-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 74 percent / H₂ / Pd/C / ethyl acetate

2: Et₃N / CH₂Cl₂

3: KO^tBu / tetrahydrofuran; benzene / 0 °C

4: LiAlH₄

5: Et₃N

6: LiAlH₄

7: p-TsOH / dioxane

With lithium aluminium tetrahydride; potassium tert-butylate; hydrogen; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; benzene;

DOI:10.1016/S0040-4039(00)98161-9

Reference yield:

(3bS,6R,8aS,8bS,10aR)-10-Methoxy-3a,5a-dimethyl-6-[(1R,4R)-1-methyl-4-((1R,2R)-2-methyl-cyclopropyl)-pentyl]-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene (99478-02-1) → (8S,9S,14S,17R)-10,13-Dimethyl-17-[(1R,4R)-1-methyl-4-((1R,2R)-2-methyl-cyclopropyl)-pentyl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol (67314-15-2,91279-13-9,91279-14-0,91279-15-1)

Guidance literature:

With toluene-4-sulfonic acid; In 1,4-dioxane;

DOI:10.1016/S0040-4039(00)98161-9

Reference yield:

{(1R,2S)-2-[(1R,4R)-4-((3bS,6R,8aS,8bS,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-1-methyl-pentyl]-cyclopropyl}-methanol (99478-00-9) → (8S,9S,14S,17R)-10,13-Dimethyl-17-[(1R,4R)-1-methyl-4-((1R,2R)-2-methyl-cyclopropyl)-pentyl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol (67314-15-2,91279-13-9,91279-14-0,91279-15-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N

2: LiAlH₄

3: p-TsOH / dioxane

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; triethylamine; In 1,4-dioxane;

DOI:10.1016/S0040-4039(00)98161-9

upstream raw materials:

(3bS,6R,8aS,8bS,10aR)-10-Methoxy-3a,5a-dimethyl-6-[(1R,4R)-1-methyl-4-((1R,2R)-2-methyl-cyclopropyl)-pentyl]-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene

{(1R,2S)-2-[(1R,4R)-4-((3bS,6R,8aS,8bS,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-1-methyl-pentyl]-cyclopropyl}-methanol

(4R,5R,8R)-4-Hydroxy-8-((3bS,6R,8aS,8bS,10aR)-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-5-methyl-nonanoic acid isopropyl ester

Methanesulfonic acid (1R,2S)-2-[(1R,4R)-4-((3bS,6R,8aS,8bS,10aR)-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-1-methyl-pentyl]-cyclopropylmethyl ester

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