(3RS,4SR) 4-fluoromethyl 1-<(1-phenylmethyl)-1-H tetrazol-5-yl> 3-tritylamino azetidin-2-one

Base Information

• Chemical Name: (3RS,4SR) 4-fluoromethyl 1-<(1-phenylmethyl)-1-H tetrazol-5-yl> 3-tritylamino azetidin-2-one
• CAS No.: 107795-26-6
• Molecular Formula: C₃₁H₂₇FN₆O
• Molecular Weight: 518.593
• Mol file: 107795-26-6.mol

Synonyms:

Chemical Property of (3RS,4SR) 4-fluoromethyl 1-<(1-phenylmethyl)-1-H tetrazol-5-yl> 3-tritylamino azetidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3RS,4SR) 4-fluoromethyl 1-<(1-phenylmethyl)-1-H tetrazol-5-yl> 3-tritylamino azetidin-2-one

There total 15 articles about (3RS,4SR) 4-fluoromethyl 1-<(1-phenylmethyl)-1-H tetrazol-5-yl> 3-tritylamino azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzyl isocyanide (88333-03-3,10340-91-7) → (3S,4S) 4-fluoromethyl 1-<(1-phenylmethyl)-1-H tetrazol-5-yl>-3-tritylamino azetidin-2-one (107795-26-6)

Guidance literature:

Multi-step reaction with 4 steps

1: chlorine / acetonitrile / -30 - -20 °C

2: 72 percent / sodium azide / acetonitrile / 20 h / 40 °C

3: 80 percent / potassium fluoride, 18-Crown-6 / acetonitrile / 65 h / Heating

4: 1.) sodium bis(trimethylsilyl)amide / 1.) THF, -30 deg C, 5 min, 2.) toluene, THF, 20 deg C, 15 min

With potassium fluoride; sodium azide; 18-crown-6 ether; sodium hexamethyldisilazane; chlorine; In acetonitrile;

DOI:10.1016/S0040-4020(01)90553-8

Reference yield:

Benzyl isocyanide (88333-03-3,10340-91-7) → (3RS,4SR) 4-fluoromethyl 1-<(1-phenylmethyl)-1-H tetrazol-5-yl> 3-tritylamino azetidin-2-one (93607-95-5,107699-53-6,107795-26-6)

Guidance literature:

Multi-step reaction with 4 steps

1: chlorine / acetonitrile / -30 - -20 °C

2: 72 percent / sodium azide / acetonitrile / 20 h / 40 °C

3: 80 percent / potassium fluoride, 18-Crown-6 / acetonitrile / 65 h / Heating

4: 1.) sodium bis(trimethylsilyl)amide / 1.) THF, -30 deg C, 5 min, 2.) toluene, THF, 20 deg C, 15 min

With potassium fluoride; sodium azide; 18-crown-6 ether; sodium hexamethyldisilazane; chlorine; In acetonitrile;

DOI:10.1016/S0040-4020(01)90553-8

Reference yield:

dichlorure de l'acide N-(phenylmethyl) carbonimidique (6181-92-6) → (3S,4S) 4-fluoromethyl 1-<(1-phenylmethyl)-1-H tetrazol-5-yl>-3-tritylamino azetidin-2-one (107795-26-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / sodium azide / acetonitrile / 20 h / 40 °C

2: 80 percent / potassium fluoride, 18-Crown-6 / acetonitrile / 65 h / Heating

3: 1.) sodium bis(trimethylsilyl)amide / 1.) THF, -30 deg C, 5 min, 2.) toluene, THF, 20 deg C, 15 min

With potassium fluoride; sodium azide; 18-crown-6 ether; sodium hexamethyldisilazane; In acetonitrile;

DOI:10.1016/S0040-4020(01)90553-8

upstream raw materials:

1-phenylmethyl 5-fluoro 1-H-tetrazole

(3S,4S) 4-fluoromethyl 3-tritylamino-azetidin-2-one

Benzyl isocyanide

dichlorure de l'acide N-(phenylmethyl) carbonimidique