(+/-)-α-hydroxy(cyclohexylmethyl)ferrocene

Base Information

• Chemical Name: (+/-)-α-hydroxy(cyclohexylmethyl)ferrocene
• CAS No.: 12094-90-5
• Molecular Formula: C₁₇H₂₂FeO
• Molecular Weight: 298.208
• Mol file: 12094-90-5.mol

Synonyms:

Chemical Property of (+/-)-α-hydroxy(cyclohexylmethyl)ferrocene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-α-hydroxy(cyclohexylmethyl)ferrocene

There total 3 articles about (+/-)-α-hydroxy(cyclohexylmethyl)ferrocene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

lithium borohydride + cyclohexylcarbonylferrocene → (+/-)-α-hydroxy(cyclohexylmethyl)ferrocene (12094-90-5,185459-02-3,185459-06-7)

Guidance literature:

In methanol; lithium borohydride (5.0 equiv.) added to a soln. of the ferrocenyl ketone (1.0 equiv.) in methanol, stirred at room temp. overnight (16 h), water added; extracted with ether, dried (MgSO4), concentrated in vacuo, crude product purified by flash column chromy. on silica gel (TLC Rf 0.47 (1:3 ether-hexane)), elem. anal.;

DOI:10.1039/b000833h

Reference yield:

cyclohexylcarbonylferrocene → (+/-)-α-hydroxy(cyclohexylmethyl)ferrocene (12094-90-5,185459-02-3,185459-06-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; 1,2-dimethoxyethane; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.10.011

Reference yield:

sodium tetrahydroborate (16940-66-2) + cyclohexylcarbonylferrocene → (+/-)-α-hydroxy(cyclohexylmethyl)ferrocene (12094-90-5,185459-02-3,185459-06-7)

Guidance literature:

In methanol; room temp., 16 h;

DOI:10.1039/b000833h

upstream raw materials:

sodium tetrahydroborate

Downstream raw materials:

(C₅H₅)Fe(C₅H₃)CH(OH)Cy(CPh₂OH)