C₁₈H₂₀N₄O

Base Information

Chemical Name:C₁₈H₂₀N₄O
CAS No.:1365534-14-0
Molecular Formula:C₁₈H₂₀N₄O
Molecular Weight:308.383
Hs Code.:

C<sub>18</sub>H<sub>20</sub>N<sub>4</sub>O

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₈H₂₀N₄O

Chemical Property:

Purity/Quality:

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Technology Process of C₁₈H₂₀N₄O

There total 8 articles about C₁₈H₂₀N₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98027-84-0
2,6-dichloro-4-iodopyridine

: 1365534-14-0
C₁₈H₂₀N₄O

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / Reflux

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 170 °C / Microwave irradiation

3: potassium hydroxide / ethanol; water / 50 °C

4: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

5: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tert-butyl alcohol / 130 °C / Microwave irradiation

6: tetrabutyl ammonium fluoride; ethylenediamine / N,N-dimethyl-formamide / 85 °C

7: trifluoroacetic acid / dichloromethane

With bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; tetrabutyl ammonium fluoride; sodium hydride; sodium carbonate; ethylenediamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.041

Reference yield:

: 1356998-56-5
2-tert-butoxy-6-chloro-4-iodopyridine

: 1365534-14-0
C₁₈H₂₀N₄O

Guidance literature:: Multi-step reaction with 6 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 170 °C / Microwave irradiation

2: potassium hydroxide / ethanol; water / 50 °C

3: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tert-butyl alcohol / 130 °C / Microwave irradiation

5: tetrabutyl ammonium fluoride; ethylenediamine / N,N-dimethyl-formamide / 85 °C

6: trifluoroacetic acid / dichloromethane

With bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; tetrabutyl ammonium fluoride; sodium hydride; sodium carbonate; ethylenediamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; potassium hydroxide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.041

Reference yield:

: 1365534-21-9
C₂₂H₃₀ClN₃O₂Si

: 1365534-14-0
C₁₈H₂₀N₄O

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / tert-butyl alcohol / 130 °C / Microwave irradiation

2: tetrabutyl ammonium fluoride; ethylenediamine / N,N-dimethyl-formamide / 85 °C

3: trifluoroacetic acid / dichloromethane

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; tetrabutyl ammonium fluoride; ethylenediamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2012.01.041