Acetic acid 8-acetoxy-5-hydroxy-2-phenyl-6-((3aR,4R,5aS,9aS,9bR)-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxin-4-ylamino)-hexahydro-benzo[1,3]dioxin-7-yl ester

Base Information

• Chemical Name: Acetic acid 8-acetoxy-5-hydroxy-2-phenyl-6-((3aR,4R,5aS,9aS,9bR)-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxin-4-ylamino)-hexahydro-benzo[1,3]dioxin-7-yl ester
• CAS No.: 82252-22-0
• Molecular Formula: C₃₁H₄₃NO₁₁
• Molecular Weight: 605.683

Synonyms:

Chemical Property of Acetic acid 8-acetoxy-5-hydroxy-2-phenyl-6-((3aR,4R,5aS,9aS,9bR)-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxin-4-ylamino)-hexahydro-benzo[1,3]dioxin-7-yl ester

Chemical Property:

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Safty Information:

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Useful:

Technology Process of Acetic acid 8-acetoxy-5-hydroxy-2-phenyl-6-((3aR,4R,5aS,9aS,9bR)-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxin-4-ylamino)-hexahydro-benzo[1,3]dioxin-7-yl ester

There total 3 articles about Acetic acid 8-acetoxy-5-hydroxy-2-phenyl-6-((3aR,4R,5aS,9aS,9bR)-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxin-4-ylamino)-hexahydro-benzo[1,3]dioxin-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

DL-3,4-di-O-acetyl-1,2-anhydro-5,7-O-benzylidene-(1,2,4,6/3,5)-6-hydroxymethyl-1,2,3,4,5-cyclohexanepentol (77144-73-1,101758-36-5) + DL-2,3:4,7-di-O-isopropylidene-(1,2,4/3,5)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexylamine (79527-15-4,90025-01-7) → Acetic acid 8-acetoxy-6-hydroxy-2-phenyl-5-((3aR,4R,5aS,9aS,9bR)-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxin-4-ylamino)-hexahydro-benzo[1,3]dioxin-7-yl ester (82252-21-9) + Acetic acid 8-acetoxy-5-hydroxy-2-phenyl-6-((3aR,4R,5aS,9aS,9bR)-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxin-4-ylamino)-hexahydro-benzo[1,3]dioxin-7-yl ester (82252-22-0)

Guidance literature:

In isopropyl alcohol; at 120 ℃; for 216h; in sealed tube;

DOI:10.1246/cl.1982.749

Reference yield:

DL-Trihydroxy(hydroxymethyl)cyclohexylamine + DL-3,4-di-O-acetyl-1,2-anhydro-5,7-O-benzylidene-(1,2,4,6/3,5)-6-hydroxymethyl-1,2,3,4,5-cyclohexanepentol (77144-73-1,101758-36-5) → Acetic acid (4aS,5R,6S,7R,8R,8aS)-8-acetoxy-6-hydroxy-2-phenyl-5-((3aR,4S,5aS,9aS,9bR)-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxin-4-ylamino)-hexahydro-benzo[1,3]dioxin-7-yl ester (82252-21-9) + N-<(1SR)-3,4-di-O-acetyl-5,7-O-benzylidene-(1,3,5/2,4,6)-2,3,4,5-tetrahydroxy-6-(hydroxymethyl)cyclohexyl>-(1SR)-2,3:4,7-di-O-isopropylidenevalidamine (82252-21-9) + Acetic acid (4aR,5S,6R,7R,8R,8aS)-8-acetoxy-5-hydroxy-2-phenyl-6-((3aR,4S,5aS,9aS,9bR)-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxin-4-ylamino)-hexahydro-benzo[1,3]dioxin-7-yl ester (82252-22-0) + N-<(1SR)-2,3-di-O-acetyl-4,7-O-benzylidene-(1,2,4/3,5,6)-2,3,4,6-tetrahydroxy-5-(hydroxymethyl)cyclohexyl>-(1SR)-2,3:4,7-di-O-isopropylidenevalidamine (82252-22-0)

Guidance literature:

In isopropyl alcohol; at 120 ℃; for 216h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00188a016

Reference yield:

DL-Trihydroxy(hydroxymethyl)cyclohexylamine + DL-3,4-di-O-acetyl-1,2-anhydro-5,7-O-benzylidene-(1,2,4,6/3,5)-6-hydroxymethyl-1,2,3,4,5-cyclohexanepentol (77144-73-1,101758-36-5) → Acetic acid (4aS,5R,6S,7R,8R,8aS)-8-acetoxy-6-hydroxy-2-phenyl-5-((3aR,4S,5aS,9aS,9bR)-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxin-4-ylamino)-hexahydro-benzo[1,3]dioxin-7-yl ester (82252-21-9) + N-<(1SR)-3,4-di-O-acetyl-5,7-O-benzylidene-(1,3,5/2,4,6)-2,3,4,5-tetrahydroxy-6-(hydroxymethyl)cyclohexyl>-(1SR)-2,3:4,7-di-O-isopropylidenevalidamine (82252-21-9) + Acetic acid (4aR,5S,6R,7R,8R,8aS)-8-acetoxy-5-hydroxy-2-phenyl-6-((3aR,4S,5aS,9aS,9bR)-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxin-4-ylamino)-hexahydro-benzo[1,3]dioxin-7-yl ester (82252-22-0) + N-<(1SR)-2,3-di-O-acetyl-4,7-O-benzylidene-(1,2,4/3,5,6)-2,3,4,6-tetrahydroxy-5-(hydroxymethyl)cyclohexyl>-(1SR)-2,3:4,7-di-O-isopropylidenevalidamine (82252-22-0)

Guidance literature:

In isopropyl alcohol; at 120 ℃; for 216h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00188a016

upstream raw materials:

DL-3,4-di-O-acetyl-1,2-anhydro-5,7-O-benzylidene-(1,2,4,6/3,5)-6-hydroxymethyl-1,2,3,4,5-cyclohexanepentol

DL-2,3:4,7-di-O-isopropylidene-(1,2,4/3,5)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexylamine

Downstream raw materials:

N-<(1RS)-2,3-di-O-acetyl-4,7-O-benzylidene-(1,2,4/3,5,6)-6-chloro-2,3,4 trihydroxy-5-(hydroxymethyl)cyclohexyl>-(1RS)-2,3:4,7-di-O-isopropylidenevalidamine

N-<(1SR)-5,6-di-O-acetyl-4,7O-benzylidene-(1,4,6/5)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexenyl>-(1SR)-2,3:4,7-di-O-isopropylidenevalidamine

(1SR)-epimino>-(1SR)-3,4-di-O-acetyl-5,7-O-benzylidene-(1,2,3,5/4,6)-3,4,5-trihydroxy-6-(hydroxymethyl)cyclohexane

N-<(1SR)-2,3,6-tri-O-acetyl-4,7-O-benzylidene-(1,2,4/3,5,6)-2,3,4,6-tetrahydroxy-5-(hydroxymethyl)cyclohexyl>-(1SR)-2,3:4,7-di-O-isopropylidenevalidamine

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