Technology Process of 2-Diphenylacetyl-5-pentyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester
There total 11 articles about 2-Diphenylacetyl-5-pentyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: tetrahydrofuran / Ambient temperature
2: H2SO4 / methanol / 4 h / Heating
3: 4.5 N HCl / Heating
4: H+
5: LiBH4
6: triethylamine / CH2Cl2 / 1 h / 0 °C
7: 1.) NaH / 1.) EtOH, 5 min, 2.) EtOH, RT, overnight
8: P2O5 / toluene / 4 h / Heating
9: NaCNBH3 / acetic acid / 0.25 h / Ambient temperature
10: 1.) KOH, 2.) sulfuric acid / 1.) methanol, reflux, 4 h, 2.) reflux, 4 h
11: 1.) diisopropylethylamine / 1.) THF, 5 min, 2.) THF, RT, overnight
With
hydrogenchloride; potassium hydroxide; lithium borohydride; sulfuric acid; phosphorus pentoxide; hydrogen cation; sodium hydride; sodium cyanoborohydride; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; acetic acid; toluene;
DOI:10.1021/jm00077a001
- Guidance literature:
-
Multi-step reaction with 7 steps
1: LiBH4
2: triethylamine / CH2Cl2 / 1 h / 0 °C
3: 1.) NaH / 1.) EtOH, 5 min, 2.) EtOH, RT, overnight
4: P2O5 / toluene / 4 h / Heating
5: NaCNBH3 / acetic acid / 0.25 h / Ambient temperature
6: 1.) KOH, 2.) sulfuric acid / 1.) methanol, reflux, 4 h, 2.) reflux, 4 h
7: 1.) diisopropylethylamine / 1.) THF, 5 min, 2.) THF, RT, overnight
With
potassium hydroxide; lithium borohydride; sulfuric acid; phosphorus pentoxide; sodium hydride; sodium cyanoborohydride; triethylamine; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; acetic acid; toluene;
DOI:10.1021/jm00077a001
- Guidance literature:
-
Multi-step reaction with 8 steps
1: H+
2: LiBH4
3: triethylamine / CH2Cl2 / 1 h / 0 °C
4: 1.) NaH / 1.) EtOH, 5 min, 2.) EtOH, RT, overnight
5: P2O5 / toluene / 4 h / Heating
6: NaCNBH3 / acetic acid / 0.25 h / Ambient temperature
7: 1.) KOH, 2.) sulfuric acid / 1.) methanol, reflux, 4 h, 2.) reflux, 4 h
8: 1.) diisopropylethylamine / 1.) THF, 5 min, 2.) THF, RT, overnight
With
potassium hydroxide; lithium borohydride; sulfuric acid; phosphorus pentoxide; hydrogen cation; sodium hydride; sodium cyanoborohydride; triethylamine; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; acetic acid; toluene;
DOI:10.1021/jm00077a001
