Acetic acid 2-{(2R,3R,4R,5R)-2-{diisopropylamino-[2-(4-nitro-phenyl)-ethoxy]-phosphanyloxymethyl}-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxysulfonyloxy]-tetrahydro-furan-3-yloxy}-ethyl ester

Base Information

• Chemical Name: Acetic acid 2-{(2R,3R,4R,5R)-2-{diisopropylamino-[2-(4-nitro-phenyl)-ethoxy]-phosphanyloxymethyl}-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxysulfonyloxy]-tetrahydro-furan-3-yloxy}-ethyl ester
• CAS No.: 179397-58-1
• Molecular Formula: C₄₅H₅₄N₉O₁₈PS
• Molecular Weight: 1072.01

Synonyms:

Chemical Property of Acetic acid 2-{(2R,3R,4R,5R)-2-{diisopropylamino-[2-(4-nitro-phenyl)-ethoxy]-phosphanyloxymethyl}-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxysulfonyloxy]-tetrahydro-furan-3-yloxy}-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid 2-{(2R,3R,4R,5R)-2-{diisopropylamino-[2-(4-nitro-phenyl)-ethoxy]-phosphanyloxymethyl}-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxysulfonyloxy]-tetrahydro-furan-3-yloxy}-ethyl ester

There total 7 articles about Acetic acid 2-{(2R,3R,4R,5R)-2-{diisopropylamino-[2-(4-nitro-phenyl)-ethoxy]-phosphanyloxymethyl}-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxysulfonyloxy]-tetrahydro-furan-3-yloxy}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane (108787-34-4) + Acetic acid 2-{(2R,3R,4R,5R)-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxysulfonyloxy]-tetrahydro-furan-3-yloxy}-ethyl ester (179397-57-0) → Acetic acid 2-{(2R,3R,4R,5R)-2-{diisopropylamino-[2-(4-nitro-phenyl)-ethoxy]-phosphanyloxymethyl}-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxysulfonyloxy]-tetrahydro-furan-3-yloxy}-ethyl ester (179397-58-1)

Guidance literature:

With 1H-tetrazole; In acetonitrile; for 3h; Ambient temperature;

DOI:10.1002/hlca.19960790314

Reference yield:

1-methyl-3-[2-(4-nitrophenyl)ethoxycarbonyl]imidazolium chloride (88091-70-7) → Acetic acid 2-{(2R,3R,4R,5R)-2-{diisopropylamino-[2-(4-nitro-phenyl)-ethoxy]-phosphanyloxymethyl}-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxysulfonyloxy]-tetrahydro-furan-3-yloxy}-ethyl ester (179397-58-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / hexamethyldisilazane, (NH₄)2SO₄ / CH₂Cl₂

2: 81 percent / pyridine / 72 h / Ambient temperature

3: 85 percent / pyridine / 4 h / Ambient temperature

4: 94 percent / 2percent toluene-4-sulfonic acid / methanol; CHCl₃ / 0.25 h / Ambient temperature

5: 59 percent / 1H-tetrazole / acetonitrile / 3 h / Ambient temperature

With pyridine; 1H-tetrazole; ammonium sulfate; toluene-4-sulfonic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; dichloromethane; chloroform; acetonitrile;

DOI:10.1002/hlca.19960790314

Reference yield:

3'-O-(2-acetoxyethyl)adenosine (179397-50-3) → Acetic acid 2-{(2R,3R,4R,5R)-2-{diisopropylamino-[2-(4-nitro-phenyl)-ethoxy]-phosphanyloxymethyl}-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxysulfonyloxy]-tetrahydro-furan-3-yloxy}-ethyl ester (179397-58-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / hexamethyldisilazane, (NH₄)2SO₄ / CH₂Cl₂

2: 81 percent / pyridine / 72 h / Ambient temperature

3: 85 percent / pyridine / 4 h / Ambient temperature

4: 94 percent / 2percent toluene-4-sulfonic acid / methanol; CHCl₃ / 0.25 h / Ambient temperature

5: 59 percent / 1H-tetrazole / acetonitrile / 3 h / Ambient temperature

With pyridine; 1H-tetrazole; ammonium sulfate; toluene-4-sulfonic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; dichloromethane; chloroform; acetonitrile;

DOI:10.1002/hlca.19960790314

upstream raw materials:

bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane

Acetic acid 2-{(2R,3R,4R,5R)-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxysulfonyloxy]-tetrahydro-furan-3-yloxy}-ethyl ester

1-methyl-3-[2-(4-nitrophenyl)ethoxycarbonyl]imidazolium chloride

3'-O-(2-acetoxyethyl)adenosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 179397-58-1 Acetic acid 2-{(2R,3R,4R,5R)-2-{diisopropylamino-[2-(4-nitro-phenyl)-ethoxy]-phosphanyloxymethyl}-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxysulfonyloxy]-tetrahydro-furan-3-yloxy}-ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send