2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid

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Chemical Name:2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid
CAS No.:139347-06-1
Molecular Formula:C₂₁H₂₉N₆O₇P
Molecular Weight:508.471
Hs Code.:

2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid

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Chemical Property of 2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid

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Technology Process of 2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid

There total 10 articles about 2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 139347-10-7,139347-11-8
methyl D,L-<(N²acetyl-N¹⁰-formyl-5,6,7,8-tetrahydro-5-deazapteroyl)amino>-4-(diethoxyphosphinyl)butanoate

: 139347-06-1,139347-16-3
2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid

Guidance literature:: With sodium hydroxide; In dimethyl sulfoxide; at 80 ℃; for 0.5h;
DOI:10.1021/jm00087a012

Reference yield:

: 87373-56-6
2-acetamido-6-formyl-4(3H)-oxopyrido<2,3-d>pyrimidine

: 139347-06-1,139347-16-3
2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid / 18 h / Ambient temperature

2: BH₃*NEt₃ / acetic acid / 0.5 h / 20 - 60 °C

3: 93 percent / H₂O / 1.5 h / 80 °C

4: 46 percent / H₂ / PtO₂*H₂O / trifluoroacetic acid / 18 h / 2280 Torr

5: Et₃N, i-BuOCOCl / dimethylformamide / 0.08 h / Ambient temperature

6: Et₃N, i-BuOCOCl / dimethylformamide

7: 50 percent / 0.5 M NaOH / dimethylsulfoxide / 0.5 h / 80 °C

With sodium hydroxide; triethylamine-borane; hydrogen; triethylamine; isobutyl chloroformate; platinum(IV) oxide; In water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1021/jm00087a012

Reference yield:

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 139347-06-1,139347-16-3
2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid / 18 h / Ambient temperature

2: BH₃*NEt₃ / acetic acid / 0.5 h / 20 - 60 °C

3: 93 percent / H₂O / 1.5 h / 80 °C

4: 46 percent / H₂ / PtO₂*H₂O / trifluoroacetic acid / 18 h / 2280 Torr

5: Et₃N, i-BuOCOCl / dimethylformamide / 0.08 h / Ambient temperature

6: Et₃N, i-BuOCOCl / dimethylformamide

7: 50 percent / 0.5 M NaOH / dimethylsulfoxide / 0.5 h / 80 °C

With sodium hydroxide; triethylamine-borane; hydrogen; triethylamine; isobutyl chloroformate; platinum(IV) oxide; In water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1021/jm00087a012