(1S,3S)-3-((1S,2S)-2-Amino-3-cyclohexyl-1-hydroxy-propyl)-2,2-dimethyl-cyclopropanecarboxylic acid; compound with trifluoro-acetic acid

Base Information

Chemical Name:(1S,3S)-3-((1S,2S)-2-Amino-3-cyclohexyl-1-hydroxy-propyl)-2,2-dimethyl-cyclopropanecarboxylic acid; compound with trifluoro-acetic acid
CAS No.:129446-03-3
Molecular Formula:C₂HF₃O₂*C₁₅H₂₇NO₃
Molecular Weight:383.408
Hs Code.:

(1S,3S)-3-((1S,2S)-2-Amino-3-cyclohexyl-1-hydroxy-propyl)-2,2-dimethyl-cyclopropanecarboxylic acid; compound with trifluoro-acetic acid

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Chemical Property of (1S,3S)-3-((1S,2S)-2-Amino-3-cyclohexyl-1-hydroxy-propyl)-2,2-dimethyl-cyclopropanecarboxylic acid; compound with trifluoro-acetic acid

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Technology Process of (1S,3S)-3-((1S,2S)-2-Amino-3-cyclohexyl-1-hydroxy-propyl)-2,2-dimethyl-cyclopropanecarboxylic acid; compound with trifluoro-acetic acid

There total 5 articles about (1S,3S)-3-((1S,2S)-2-Amino-3-cyclohexyl-1-hydroxy-propyl)-2,2-dimethyl-cyclopropanecarboxylic acid; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121079-58-1,129396-82-3
((S)-1-Cyclohexylmethyl-2-hydroxy-4-methyl-pent-3-enyl)-carbamic acid tert-butyl ester

: 129446-03-3
(1S,3S)-3-((1S,2S)-2-Amino-3-cyclohexyl-1-hydroxy-propyl)-2,2-dimethyl-cyclopropanecarboxylic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: p-TSA / CH₂Cl₂

2: CuSO₄ / 90 °C

3: p-TSA / methanol / 6 h / Ambient temperature

4: 1.) 0 deg C 2.) r.t.

With toluene-4-sulfonic acid; copper(II) sulfate; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(00)94403-4

Reference yield:

: 121079-59-2
(S)-4-Cyclohexylmethyl-2,2-dimethyl-5-(2-methyl-propenyl)-oxazolidine-3-carboxylic acid tert-butyl ester

: 129446-03-3
(1S,3S)-3-((1S,2S)-2-Amino-3-cyclohexyl-1-hydroxy-propyl)-2,2-dimethyl-cyclopropanecarboxylic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: CuSO₄ / 90 °C

2: p-TSA / methanol / 6 h / Ambient temperature

3: 1.) 0 deg C 2.) r.t.

With toluene-4-sulfonic acid; copper(II) sulfate; In methanol;
DOI:10.1016/S0040-4039(00)94403-4

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 129446-03-3
(1S,3S)-3-((1S,2S)-2-Amino-3-cyclohexyl-1-hydroxy-propyl)-2,2-dimethyl-cyclopropanecarboxylic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / -55 °C

2: p-TSA / CH₂Cl₂

3: CuSO₄ / 90 °C

4: p-TSA / methanol / 6 h / Ambient temperature

5: 1.) 0 deg C 2.) r.t.

With toluene-4-sulfonic acid; copper(II) sulfate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4039(00)94403-4