C₁₄H₁₆INO₄

Base Information

• Chemical Name: C₁₄H₁₆INO₄
• CAS No.: 1334223-57-2
• Molecular Formula: C₁₄H₁₆INO₄
• Molecular Weight: 389.19
• Mol file: 1334223-57-2.mol

Synonyms:

Chemical Property of C₁₄H₁₆INO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₆INO₄

There total 3 articles about C₁₄H₁₆INO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + C9H8INO3 (1334223-48-1) → C14H16INO4 (1334223-57-2)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1002/anie.201103318

Reference yield:

C11H10INO4 (1334223-42-5) → C14H16INO4 (1334223-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / dichloromethane / 3 h / -78 °C / Inert atmosphere

2: pyridinium p-toluenesulfonate / dichloromethane / 6 h / 20 °C / Inert atmosphere

With pyridinium p-toluenesulfonate; diisobutylaluminium hydride; In dichloromethane;

DOI:10.1002/anie.201103318

Reference yield:

3-nitro-benzaldehyde (99-61-6) → C14H16INO4 (1334223-57-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: iodine; potassium carbonate / methanol / 1.5 h / 0 - 5 °C / Inert atmosphere

1.2: 40 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane / 3 h / -78 °C / Inert atmosphere

3.1: pyridinium p-toluenesulfonate / dichloromethane / 6 h / 20 °C / Inert atmosphere

With iodine; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; In methanol; dichloromethane; 1.1: Wittig reaction / 1.2: Wittig reaction;

DOI:10.1002/anie.201103318

upstream raw materials:

3,4-dihydro-2H-pyran

C₉H₈INO₃

C₁₁H₁₀INO₄

3-nitro-benzaldehyde