N-<2-(Triphenylphosphonio)ethoxycarbonyl>leucyl-N⁴-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-β-D-glucopyranosyl)-asparagin-tert-butylester-chlorid

Base Information

• Chemical Name: N-<2-(Triphenylphosphonio)ethoxycarbonyl>leucyl-N⁴-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-β-D-glucopyranosyl)-asparagin-tert-butylester-chlorid
• CAS No.: 86040-90-6
• Molecular Formula: C₄₉H₆₄N₄O₁₄P*Cl
• Molecular Weight: 999.492
• Mol file: 86040-90-6.mol

Synonyms:

Chemical Property of N-<2-(Triphenylphosphonio)ethoxycarbonyl>leucyl-N⁴-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-β-D-glucopyranosyl)-asparagin-tert-butylester-chlorid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<2-(Triphenylphosphonio)ethoxycarbonyl>leucyl-N⁴-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-β-D-glucopyranosyl)-asparagin-tert-butylester-chlorid

There total 2 articles about N-<2-(Triphenylphosphonio)ethoxycarbonyl>leucyl-N⁴-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-β-D-glucopyranosyl)-asparagin-tert-butylester-chlorid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N-<2-(Triphenylphosphonio)ethoxycarbonyl>leucin-chlorid (61083-76-9) + N4-(2-Acetamido-3,4,6-tri-O-acetyl-2-desoxy-β-D-glucopyranosyl)-asparagin-tert-butylester (86040-79-1) → N-<2-(Triphenylphosphonio)ethoxycarbonyl>leucyl-N4-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-β-D-glucopyranosyl)-asparagin-tert-butylester-chlorid (86040-90-6)

Guidance literature:

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane; 1) -10 deg C, 1 h, 2) 15 h, room temperature;

DOI:10.1002/jlac.198319830302

Reference yield:

N4-(2-Acetamido-3,4,6-tri-O-acetyl-2-desoxy-β-D-glucopyranosyl)-N2-<2-(triphenylphosphonio)ethoxycarbonyl>asparagin-tert-butylester-chlorid (86088-20-2) → N-<2-(Triphenylphosphonio)ethoxycarbonyl>leucyl-N4-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-β-D-glucopyranosyl)-asparagin-tert-butylester-chlorid (86040-90-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / morpholine / CH₂Cl₂ / 0.33 h / Ambient temperature

2: 67 percent / (ethyl)-2-ethoxy-1,2-dihydro-1-quinolinecarboxylate / CH₂Cl₂ / 1) -10 deg C, 1 h, 2) 15 h, room temperature

With morpholine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane;

DOI:10.1002/jlac.198319830302

upstream raw materials:

N-<2-(Triphenylphosphonio)ethoxycarbonyl>leucin-chlorid

N⁴-(2-Acetamido-3,4,6-tri-O-acetyl-2-desoxy-β-D-glucopyranosyl)-asparagin-tert-butylester

N⁴-(2-Acetamido-3,4,6-tri-O-acetyl-2-desoxy-β-D-glucopyranosyl)-N²-<2-(triphenylphosphonio)ethoxycarbonyl>asparagin-tert-butylester-chlorid