Hexahydro-8a-hydroxy-1-(2-phenylethyl)spiro-2(3H)-thion

Base Information

Chemical Name:Hexahydro-8a-hydroxy-1-(2-phenylethyl)spiro-2(3H)-thion
CAS No.:78102-48-4
Molecular Formula:C₂₁H₃₀N₂OS
Molecular Weight:358.548
Hs Code.:

Hexahydro-8a-hydroxy-1-(2-phenylethyl)spiro<chinazolin-4(1H),1'-cyclohexan>-2(3H)-thion

Synonyms:

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Chemical Property of Hexahydro-8a-hydroxy-1-(2-phenylethyl)spiro-2(3H)-thion

Chemical Property:

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Technology Process of Hexahydro-8a-hydroxy-1-(2-phenylethyl)spiro-2(3H)-thion

There total 3 articles about Hexahydro-8a-hydroxy-1-(2-phenylethyl)spiro-2(3H)-thion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 58415-49-9
1'-Isothiocyanato<1,1'-bicyclohexyl>-2-on

: 64-04-0
phenethylamine

: 78102-48-4
Hexahydro-8a-hydroxy-1-(2-phenylethyl)spiro-2(3H)-thion

Guidance literature:: In ethyl acetate; for 3h; Ambient temperature;

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 78102-48-4
Hexahydro-8a-hydroxy-1-(2-phenylethyl)spiro-2(3H)-thion

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / Me₃SiCl, NaBr / 2.5 h / 34 °C / Me₃SiCl-LiBr

2: 93 percent / acetone / 48 h / 37 °C

3: 86 percent / ethyl acetate / 3 h / Ambient temperature

With chloro-trimethyl-silane; sodium bromide; In ethyl acetate; acetone;

Reference yield:

: 343774-33-4
1'-Brom<1,1'-bicyclohexyl>-2-on

: 78102-48-4
Hexahydro-8a-hydroxy-1-(2-phenylethyl)spiro-2(3H)-thion

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / acetone / 48 h / 37 °C

2: 86 percent / ethyl acetate / 3 h / Ambient temperature

In ethyl acetate; acetone;