N⁴-[4-Dimethoxymethyl-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine; compound with (E)-but-2-enedioic acid

Base Information

• Chemical Name: N⁴-[4-Dimethoxymethyl-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine; compound with (E)-but-2-enedioic acid
• CAS No.: 98510-10-2
• Molecular Formula: C₄H₄O₄*C₂₅H₃₀F₃N₃O₄
• Molecular Weight: 609.599

Synonyms:

Chemical Property of N⁴-[4-Dimethoxymethyl-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine; compound with (E)-but-2-enedioic acid

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Technology Process of N⁴-[4-Dimethoxymethyl-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine; compound with (E)-but-2-enedioic acid

There total 3 articles about N⁴-[4-Dimethoxymethyl-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine; compound with (E)-but-2-enedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Dimethoxymethyl-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamine → N4-[4-Dimethoxymethyl-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine; compound with (E)-but-2-enedioic acid (98510-10-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dimethylformamide / 90 °C

2: 1.) hydrazine / 1.) ethanol, 60 deg C, 4 h, 2.) ethanol

With triethylamine; hydrazine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00149a004

Reference yield:

4-(dimethoxymethyl)-6-methoxy-8-nitro-5-quinoline (98509-98-9) → N4-[4-Dimethoxymethyl-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine; compound with (E)-but-2-enedioic acid (98510-10-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 2N hydrochloric acid, stannous chloride, tin / tetrahydrofuran; ethanol / 1 h / 5 - 10 °C

2: triethylamine / dimethylformamide / 90 °C

3: 1.) hydrazine / 1.) ethanol, 60 deg C, 4 h, 2.) ethanol

With hydrogenchloride; tin; triethylamine; tin(ll) chloride; hydrazine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00149a004

Reference yield:

2-{4-[4-Dimethoxymethyl-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) → N4-[4-Dimethoxymethyl-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine; compound with (E)-but-2-enedioic acid (98510-10-2)

Guidance literature:

With hydrazine; Yield given. Multistep reaction; 1.) ethanol, 60 deg C, 4 h, 2.) ethanol;

DOI:10.1021/jm00149a004

upstream raw materials:

(2E)-but-2-enedioic acid

4-(dimethoxymethyl)-6-methoxy-8-nitro-5-quinoline

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