2,6-di[(4R,5R)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]-1-hexylbenzene

Base Information

• Chemical Name: 2,6-di[(4R,5R)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]-1-hexylbenzene
• CAS No.: 1268872-84-9
• Molecular Formula: C₄₂H₄₂N₄
• Molecular Weight: 602.822
• Mol file: 1268872-84-9.mol

Synonyms:

Chemical Property of 2,6-di[(4R,5R)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]-1-hexylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-di[(4R,5R)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]-1-hexylbenzene

There total 6 articles about 2,6-di[(4R,5R)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]-1-hexylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C42H46N4 → 2,6-di[(4R,5R)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]-1-hexylbenzene (1268872-84-9)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tetasy.2010.12.002

Reference yield:

2-hexylbenzene-1,3-dicarbaldehyde (1268872-71-4) → 2,6-di[(4R,5R)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]-1-hexylbenzene (1268872-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 4 h / 0 - 20 °C / Inert atmosphere

2: N-Bromosuccinimide / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; In dichloromethane; toluene;

DOI:10.1016/j.tetasy.2010.12.002

Reference yield:

2-iodoisophthalaldehyde (777854-97-4) → 2,6-di[(4R,5R)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]-1-hexylbenzene (1268872-84-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

2.1: Pd-BaSO₄; hydrogen / ethyl acetate / 24 h

2.2: 20 h

3.1: toluene / 4 h / 0 - 20 °C / Inert atmosphere

4.1: N-Bromosuccinimide / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Pd-BaSO₄; hydrogen; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene; 1.1: Sonogashira coupling / 2.2: Dess-Martin oxidation;

DOI:10.1016/j.tetasy.2010.12.002

upstream raw materials:

benzene-1,3-dicarbonitrile

2-iodoisophthalaldehyde

2-(hex-1-ynyl)benzene-1,3-dicarbaldehyde

2-hexylbenzene-1,3-dicarbaldehyde