6-(3-Trifluoromethyl-benzenesulfonyl)-octahydro-pyrido[3,4-b][1,4]thiazine

Base Information

• Chemical Name: 6-(3-Trifluoromethyl-benzenesulfonyl)-octahydro-pyrido[3,4-b][1,4]thiazine
• CAS No.: 250291-50-0
• Molecular Formula: C₁₄H₁₇F₃N₂O₂S₂
• Molecular Weight: 366.428
• Mol file: 250291-50-0.mol

Synonyms:

Chemical Property of 6-(3-Trifluoromethyl-benzenesulfonyl)-octahydro-pyrido[3,4-b][1,4]thiazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(3-Trifluoromethyl-benzenesulfonyl)-octahydro-pyrido[3,4-b][1,4]thiazine

There total 6 articles about 6-(3-Trifluoromethyl-benzenesulfonyl)-octahydro-pyrido[3,4-b][1,4]thiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(3-Trifluoromethyl-benzenesulfonyl)-2,4a,5,6,7,8-hexahydro-3H-pyrido[3,4-b][1,4]thiazine → 6-(3-Trifluoromethyl-benzenesulfonyl)-octahydro-pyrido[3,4-b][1,4]thiazine (250291-50-0)

Guidance literature:

With polymer supported cyanoborohydride; In methanol; Yield given;

DOI:10.1039/a805997g

Reference yield:

3-(Trifluoromethyl)benzenesulfonyl chloride (777-44-6) → 6-(3-Trifluoromethyl-benzenesulfonyl)-octahydro-pyrido[3,4-b][1,4]thiazine (250291-50-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 87 percent / polymer supported DMAP / CH₂Cl₂

2: polymer supported pyridinium bromide perbromide / toluene / 10 °C

3: Amberlyst A₂₁ / tetrahydrofuran

4: CF₃COOH / CH₂Cl₂

5: polymer supported cyanoborohydride / methanol

With polymer supported cyanoborohydride; amberlyst A₂₁; polymer supported DMAP; polymer supported pyridinium bromide perbromide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; toluene;

DOI:10.1039/a805997g

Reference yield:

4-piperidone hydrochloride (41979-39-9) → 6-(3-Trifluoromethyl-benzenesulfonyl)-octahydro-pyrido[3,4-b][1,4]thiazine (250291-50-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 87 percent / polymer supported DMAP / CH₂Cl₂

2: polymer supported pyridinium bromide perbromide / toluene / 10 °C

3: Amberlyst A₂₁ / tetrahydrofuran

4: CF₃COOH / CH₂Cl₂

5: polymer supported cyanoborohydride / methanol

With polymer supported cyanoborohydride; amberlyst A₂₁; polymer supported DMAP; polymer supported pyridinium bromide perbromide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; toluene;

DOI:10.1039/a805997g

upstream raw materials:

3-(Trifluoromethyl)benzenesulfonyl chloride

4-piperidone hydrochloride

1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-one

3-Bromo-1-(3-trifluoromethyl-benzenesulfonyl)-piperidin-4-one

Downstream raw materials:

6-(3-Trifluoromethyl-benzenesulfonyl)-octahydro-pyrido[3,4-b][1,4]thiazine-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide

6-(3-Trifluoromethyl-benzenesulfonyl)-octahydro-pyrido[3,4-b][1,4]thiazine-1-carboxylic acid (3,4-dichloro-phenyl)-amide

6-(3-Trifluoromethyl-benzenesulfonyl)-octahydro-pyrido[3,4-b][1,4]thiazine-1-carboxylic acid (4-methoxy-phenyl)-amide

6-(3-Trifluoromethyl-benzenesulfonyl)-octahydro-pyrido[3,4-b][1,4]thiazine-1-carboxylic acid phenylamide