3-hydroxy-6-methoxy-3,4-dihydro-2(1H)-quinolinone

Base Information

Chemical Name:3-hydroxy-6-methoxy-3,4-dihydro-2(1H)-quinolinone
CAS No.:301155-97-5
Molecular Formula:C₁₀H₁₁NO₃
Molecular Weight:193.202
Hs Code.:
DSSTox Substance ID:DTXSID101232952
Nikkaji Number:J1.350.629I
Mol file:301155-97-5.mol

Synonyms:3-hydroxy-6-methoxy-3,4-dihydro-2(1H)-quinolinone;301155-97-5;3-hydroxy-6-methoxy-3,4-dihydro-1H-quinolin-2-one;DTXSID101232952;KUC106819N;AKOS006292185;KSC-11-239-2;AQ-776/42801590;3,4-Dihydro-3-hydroxy-6-methoxy-2(1H)-quinolinone

Suppliers and Price of 3-hydroxy-6-methoxy-3,4-dihydro-2(1H)-quinolinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-hydroxy-6-methoxy-3,4-dihydro-2(1H)-quinolinone

Chemical Property:

XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:193.07389321
Heavy Atom Count:14
Complexity:231

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC2=C(C=C1)NC(=O)C(C2)O

Technology Process of 3-hydroxy-6-methoxy-3,4-dihydro-2(1H)-quinolinone

There total 4 articles about 3-hydroxy-6-methoxy-3,4-dihydro-2(1H)-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131761-77-8
ethyl 3-(5-methoxy-2-nitrophenyl)-2-oxopropanoate

: 301155-97-5
(R)-3-hydroxy-6-methoxy-3,4-dihydroquinolin-2(1H)-one

: 301155-97-5
(S)-3-hydroxy-6-methoxy-3,4-dihydroquinolin-2(1H)-one

Guidance literature:: With Pt/Al₂O₃; hydrogen; acetic acid; 4-[(R)-((1S,2S,4S,5R)-5-Ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methoxy-methyl]-quinoline; In toluene; at 20 ℃; under 7500.75 Torr; Overall yield = 75 %; enantioselective reaction; Autoclave;
DOI:10.1002/adsc.201300121

Reference yield:

: 131761-77-8
ethyl 3-(5-methoxy-2-nitrophenyl)-2-oxopropanoate

: 301155-97-5
(R)-3-hydroxy-6-methoxy-3,4-dihydroquinolin-2(1H)-one

: 301155-97-5
(S)-3-hydroxy-6-methoxy-3,4-dihydroquinolin-2(1H)-one

Guidance literature:: With Pt/Al₂O₃; hydrogen; acetic acid; 4-[(R)-((1S,2S,4S,5R)-5-Ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methoxy-methyl]-quinoline; In toluene; at 20 ℃; under 7500.75 Torr; Overall yield = 75 %; enantioselective reaction; Autoclave;
DOI:10.1002/adsc.201300121

Reference yield:

: 5367-32-8
5-methoxy-2-nitrotoluene

: 301155-97-5
(R)-3-hydroxy-6-methoxy-3,4-dihydroquinolin-2(1H)-one

: 301155-97-5
(S)-3-hydroxy-6-methoxy-3,4-dihydroquinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / diethyl ether / 0.17 h

1.2: 20 °C

2.1: 4-[(R)-((1S,2S,4S,5R)-5-Ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methoxy-methyl]-quinoline; hydrogen; Pt/Al₂O₃; acetic acid / toluene / 20 °C / 7500.75 Torr / Autoclave

With Pt/Al₂O₃; potassium tert-butylate; hydrogen; acetic acid; 4-[(R)-((1S,2S,4S,5R)-5-Ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methoxy-methyl]-quinoline; In diethyl ether; toluene;
DOI:10.1002/adsc.201300121