2-(4-methylpiperazin-1-yl)ethyl 3-bromophenyl(6-(methylthio)-1-(2-phenylpropyl)-1Hpyrazolo[3,4-d]pyrimidin-4-yl)carbamate

Base Information

• Chemical Name: 2-(4-methylpiperazin-1-yl)ethyl 3-bromophenyl(6-(methylthio)-1-(2-phenylpropyl)-1Hpyrazolo[3,4-d]pyrimidin-4-yl)carbamate
• CAS No.: 1437791-88-2
• Molecular Formula: C₂₉H₃₄BrN₇O₂S
• Molecular Weight: 624.605
• Mol file: 1437791-88-2.mol

Synonyms:

Chemical Property of 2-(4-methylpiperazin-1-yl)ethyl 3-bromophenyl(6-(methylthio)-1-(2-phenylpropyl)-1Hpyrazolo[3,4-d]pyrimidin-4-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methylpiperazin-1-yl)ethyl 3-bromophenyl(6-(methylthio)-1-(2-phenylpropyl)-1Hpyrazolo[3,4-d]pyrimidin-4-yl)carbamate

There total 2 articles about 2-(4-methylpiperazin-1-yl)ethyl 3-bromophenyl(6-(methylthio)-1-(2-phenylpropyl)-1Hpyrazolo[3,4-d]pyrimidin-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-piperazine (109-01-3) → 2-(4-methylpiperazin-1-yl)ethyl 3-bromophenyl(6-(methylthio)-1-(2-phenylpropyl)-1Hpyrazolo[3,4-d]pyrimidin-4-yl)carbamate (1437791-88-2)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 20 - 80 °C / Inert atmosphere

2: sodium hydride / dichloromethane; mineral oil / 6 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; In dichloromethane; toluene; mineral oil;

DOI:10.1021/ml4000782

Reference yield:

(3-bromo-phenyl)-[6-methylsulfanyl-1-(2-phenyl-propyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amine (1338789-34-6) → 2-(4-methylpiperazin-1-yl)ethyl 3-bromophenyl(6-(methylthio)-1-(2-phenylpropyl)-1Hpyrazolo[3,4-d]pyrimidin-4-yl)carbamate (1437791-88-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: dichloromethane / 16 h / 20 °C / Inert atmosphere

With sodium hydrogencarbonate; In dichloromethane;

DOI:10.1021/acs.jmedchem.7b00637

upstream raw materials:

1-methyl-piperazine

(3-bromo-phenyl)-[6-methylsulfanyl-1-(2-phenyl-propyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amine