toluene-4-sulfonic acid 3-(3-{[2-(2-cyano-ethylsulfanyl)-phenyl]-methyl-carbamoyl}-propyl)-1-hydroxy-2,2,4-trimethyl-cyclohex-3-enylmethyl ester

Base Information

• Chemical Name: toluene-4-sulfonic acid 3-(3-{[2-(2-cyano-ethylsulfanyl)-phenyl]-methyl-carbamoyl}-propyl)-1-hydroxy-2,2,4-trimethyl-cyclohex-3-enylmethyl ester
• CAS No.: 241815-02-1
• Molecular Formula: C₃₁H₄₀N₂O₅S₂
• Molecular Weight: 584.801
• Mol file: 241815-02-1.mol

Synonyms:

Chemical Property of toluene-4-sulfonic acid 3-(3-{[2-(2-cyano-ethylsulfanyl)-phenyl]-methyl-carbamoyl}-propyl)-1-hydroxy-2,2,4-trimethyl-cyclohex-3-enylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of toluene-4-sulfonic acid 3-(3-{[2-(2-cyano-ethylsulfanyl)-phenyl]-methyl-carbamoyl}-propyl)-1-hydroxy-2,2,4-trimethyl-cyclohex-3-enylmethyl ester

There total 7 articles about toluene-4-sulfonic acid 3-(3-{[2-(2-cyano-ethylsulfanyl)-phenyl]-methyl-carbamoyl}-propyl)-1-hydroxy-2,2,4-trimethyl-cyclohex-3-enylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5',5',8'a-trimethyl-3',5',8',8'a-tetrahydro-spiro<1,3-dioxolane-2,1'(2'H)naphthalene>-6'(7'H)-one (131613-90-6) → toluene-4-sulfonic acid 3-(3-{[2-(2-cyano-ethylsulfanyl)-phenyl]-methyl-carbamoyl}-propyl)-1-hydroxy-2,2,4-trimethyl-cyclohex-3-enylmethyl ester (241815-02-1)

Guidance literature:

Multi-step reaction with 9 steps

1: NaH / dimethylsulfoxide / 60 °C

2: OsO₄, H₂O, NMO / acetone / Ambient temperature

3: p-TsOH / Heating

4: 98 percent / NH₂OH*HCl, pyridine / Ambient temperature

6: (COCl)2 / benzene

7: benzene / Ambient temperature

8: HCl, H₂O / methanol / Ambient temperature

9: pyridine / Ambient temperature

With pyridine; hydrogenchloride; osmium(VIII) oxide; N-methyl-2-indolinone; oxalyl dichloride; hydroxylamine hydrochloride; water; sodium hydride; toluene-4-sulfonic acid; In methanol; dimethyl sulfoxide; acetone; benzene;

DOI:10.1055/s-1999-3101

Reference yield:

C17H26O3 (241814-99-3) → toluene-4-sulfonic acid 3-(3-{[2-(2-cyano-ethylsulfanyl)-phenyl]-methyl-carbamoyl}-propyl)-1-hydroxy-2,2,4-trimethyl-cyclohex-3-enylmethyl ester (241815-02-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 98 percent / NH₂OH*HCl, pyridine / Ambient temperature

3: (COCl)2 / benzene

4: benzene / Ambient temperature

5: HCl, H₂O / methanol / Ambient temperature

6: pyridine / Ambient temperature

With pyridine; hydrogenchloride; oxalyl dichloride; hydroxylamine hydrochloride; water; In methanol; benzene;

DOI:10.1055/s-1999-3101

Reference yield:

C17H27NO3 (241815-00-9) → toluene-4-sulfonic acid 3-(3-{[2-(2-cyano-ethylsulfanyl)-phenyl]-methyl-carbamoyl}-propyl)-1-hydroxy-2,2,4-trimethyl-cyclohex-3-enylmethyl ester (241815-02-1)

Guidance literature:

Multi-step reaction with 5 steps

2: (COCl)2 / benzene

3: benzene / Ambient temperature

4: HCl, H₂O / methanol / Ambient temperature

5: pyridine / Ambient temperature

With pyridine; hydrogenchloride; oxalyl dichloride; water; In methanol; benzene;

DOI:10.1055/s-1999-3101

upstream raw materials:

p-toluenesulfonyl chloride

5',5',8'a-trimethyl-3',5',8',8'a-tetrahydro-spiro<1,3-dioxolane-2,1'(2'H)naphthalene>-6'(7'H)-one

C₁₇H₂₆O₃

C₁₇H₂₇NO₃