1-Ethyl-1-cyclododecanol

Base Information

• Chemical Name: 1-Ethyl-1-cyclododecanol
• CAS No.: 16313-36-3
• Molecular Formula: C₁₄H₂₈O
• Molecular Weight: 212.376
• European Community (EC) Number: 653-317-7
• Mol file: 16313-36-3.mol

Synonyms:1-ETHYL-1-CYCLODODECANOL;SCHEMBL6062608;AKOS024334109

Chemical Property of 1-Ethyl-1-cyclododecanol

Chemical Property:

• XLogP3: 5.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 212.214015512
• Heavy Atom Count: 15
• Complexity: 141

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-ETHYL-1-CYCLODODECANOL AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC1(CCCCCCCCCCC1)O

Technology Process of 1-Ethyl-1-cyclododecanol

There total 2 articles about 1-Ethyl-1-cyclododecanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethylmagnesium bromide (925-90-6) + cyclododecanone (830-13-7) → 1-Aethyl-cyclododecanol-(1) (16313-36-3)

Guidance literature:

DOI:10.1016/S0040-4020(01)92842-X

Reference yield:

→ 1-Aethyl-cyclododecanol-(1) (16313-36-3)

Guidance literature:

Cyclododecanon, Aethyl-magnesiumbromid;

Reference yield:

1-Aethyl-cyclododecanol-(1) (16313-36-3) → 12-hydroxy-12-phenyltetradecanal (1357255-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

1.2: 2.5 h / -78 °C

1.3: -78 - 20 °C

2.1: trimethylsilyl trifluoromethanesulfonate; triphenylphosphine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.2: 0.17 h / 20 °C / Inert atmosphere

2.3: 2 h / 40 °C

With trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; triphenylphosphine; In dichloromethane;

DOI:10.1002/anie.201106046

upstream raw materials:

ethylmagnesium bromide

cyclododecanone

Downstream raw materials:

Ethylcyclododecan

12-hydroxy-12-phenyltetradecanal

Refernces