(R)-[10,10,11,11-2H₄]-1,12-hexadecandiol

Base Information

• Chemical Name: (R)-[10,10,11,11-2H₄]-1,12-hexadecandiol
• CAS No.: 790695-90-8
• Molecular Formula: C₁₆H₃₄O₂
• Molecular Weight: 262.413
• Mol file: 790695-90-8.mol

Synonyms:

Chemical Property of (R)-[10,10,11,11-2H₄]-1,12-hexadecandiol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-[10,10,11,11-2H₄]-1,12-hexadecandiol

There total 7 articles about (R)-[10,10,11,11-2H₄]-1,12-hexadecandiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(R)-[6,6,7,7,-2H4]-5-methoxymethyloxy-17,19-dioxaeicosane (790695-86-2) → (R)-[10,10,11,11-2H4]-1,12-hexadecandiol (790695-90-8)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 24h;

DOI:10.1021/jo049320h

Reference yield:

hept-1-yn-3-ol (7383-19-9) → (R)-[10,10,11,11-2H4]-1,12-hexadecandiol (790695-90-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: immobilized Candida antarctica lipase B; vinyl acetate / diisopropyl ether / 25 °C / Enzymatic reaction

1.2: BuLi; HMPA / tetrahydrofuran; hexane / 1 h / 20 °C

1.3: tetrahydrofuran; hexane / 20 °C

2.1: 91 percent / LiBr; TsOH

3.1: 93 percent / D₂ / RhCl(PPh₃)3 / benzene / 36 h

4.1: 87 percent / HCl / methanol / 24 h / 20 °C

With hydrogenchloride; vinyl acetate; immobilized Candida antarctica Lipase B; toluene-4-sulfonic acid; deuterium; lithium bromide; RhCl(PPh₃)3; In methanol; di-isopropyl ether; benzene;

DOI:10.1021/jo049320h

Reference yield:

1-bromo-9-(methoxymethoxy)nonane (317801-83-5) → (R)-[10,10,11,11-2H4]-1,12-hexadecandiol (790695-90-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: immobilized Candida antarctica lipase B; vinyl acetate / diisopropyl ether / 25 °C / Enzymatic reaction

1.2: BuLi; HMPA / tetrahydrofuran; hexane / 1 h / 20 °C

1.3: tetrahydrofuran; hexane / 20 °C

2.1: 91 percent / LiBr; TsOH

3.1: 93 percent / D₂ / RhCl(PPh₃)3 / benzene / 36 h

4.1: 87 percent / HCl / methanol / 24 h / 20 °C

With hydrogenchloride; vinyl acetate; immobilized Candida antarctica Lipase B; toluene-4-sulfonic acid; deuterium; lithium bromide; RhCl(PPh₃)3; In methanol; di-isopropyl ether; benzene;

DOI:10.1021/jo049320h

upstream raw materials:

(R)-[6,6,7,7,-2H₄]-5-methoxymethyloxy-17,19-dioxaeicosane

hept-1-yn-3-ol

1-bromo-9-(methoxymethoxy)nonane

(R)-(+)-17,19-dioxa-6-eicosyn-5-ol

Downstream raw materials:

(R)-[10,10,11,11,12-2H5]-hexadecanoic acid