Technology Process of 3-[5-(1-benzyloxycarbonyl-(2S)-pyrrolidinyl)-2H-tetrazol-2-yl]propionic acid ethyl ester
There total 5 articles about 3-[5-(1-benzyloxycarbonyl-(2S)-pyrrolidinyl)-2H-tetrazol-2-yl]propionic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Ethyl 3-bromopropionate; 5-<1-(benzyloxycarbonyl)pyrrolidin-2-yl>tetrazole;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 6h;
With
hydrogenchloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium azide / zinc dibromide / water; isopropyl alcohol / 15 h / Heating / reflux
1.2: 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 60 °C
2.2: 20 °C
With
sodium azide; potassium carbonate;
zinc dibromide;
In
water; N,N-dimethyl-formamide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 0.25 h / 0 °C
1.2: 15 h / 0 - 20 °C
2.1: p-toluenesulfonyl chloride / pyridine / 3 h / 100 °C
2.2: 20 °C
3.1: sodium azide / zinc dibromide / water; isopropyl alcohol / 15 h / Heating / reflux
3.2: 20 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 60 °C
4.2: 20 °C
With
4-methyl-morpholine; sodium azide; chloroformic acid ethyl ester; potassium carbonate; p-toluenesulfonyl chloride;
zinc dibromide;
In
tetrahydrofuran; pyridine; water; N,N-dimethyl-formamide; isopropyl alcohol;
