6-Hydroxyethyl sorbitol

Base Information

• Chemical Name: 6-Hydroxyethyl sorbitol
• CAS No.: 110204-70-1
• Molecular Formula: C₈H₁₈O₇
• Molecular Weight: 226.227
• UNII: TRQ60PZ09D
• DSSTox Substance ID: DTXSID001021388
• Wikidata: Q27290233
• Mol file: 110204-70-1.mol

Synonyms:6-Hydroxyethyl sorbitol;110204-70-1;TRQ60PZ09D;D-Glucitol, 6-O-(2-hydroxyethyl)-;UNII-TRQ60PZ09D;(2R,3R,4R,5S)-6-(2-hydroxyethoxy)hexane-1,2,3,4,5-pentol;SCHEMBL1161497;DTXSID001021388;Q27290233

Chemical Property of 6-Hydroxyethyl sorbitol

Chemical Property:

• XLogP3: -3.8
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 8
• Exact Mass: 226.10525291
• Heavy Atom Count: 15
• Complexity: 154

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C(COCC(C(C(C(CO)O)O)O)O)O
• Isomeric SMILES: C(COC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O

Technology Process of 6-Hydroxyethyl sorbitol

There total 2 articles about 6-Hydroxyethyl sorbitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O6-(2-hydroxy-ethyl)-D-glucose (10230-13-4) → 6-O-(hydroxyethyl)-D-glucitol (110204-70-1)

Guidance literature:

With sodium tetrahydroborate; In water; for 3h; Ambient temperature;

DOI:10.1016/0008-6215(89)84123-0

Reference yield:

3,5-O-benzylidene-1,2-O-isopropylidene-α-<*>-glucofuranose (22164-09-6,34049-09-7,74708-51-3,93301-73-6,108865-15-2) → 6-O-(hydroxyethyl)-D-glucitol (110204-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1: CF₃COOH / H₂O / 5 h / 100 °C

2: NaBH₄ / H₂O / 3 h / Ambient temperature

With sodium tetrahydroborate; trifluoroacetic acid; In water;

DOI:10.1016/0008-6215(89)84123-0

upstream raw materials:

O⁶-(2-hydroxy-ethyl)-D-glucose

3,5-O-benzylidene-1,2-O-isopropylidene-α-<*>-glucofuranose