3-(4-Fluorophenyl)spiro[isobenzofuran-1(3H),4'-piperidine]

Base Information

Chemical Name:3-(4-Fluorophenyl)spiro[isobenzofuran-1(3H),4'-piperidine]
CAS No.:59142-97-1
Molecular Formula:C₁₈H₁₈FNO
Molecular Weight:283.345
Hs Code.:
DSSTox Substance ID:DTXSID401192353

Synonyms:59142-97-1;SCHEMBL11686154;3-(4-Fluorophenyl)spiro[isobenzofuran-1(3H),4'-piperidine];DTXSID401192353

Suppliers and Price of 3-(4-Fluorophenyl)spiro[isobenzofuran-1(3H),4'-piperidine]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 3-(4-Fluorophenyl)spiro[isobenzofuran-1(3H),4'-piperidine]

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:283.137242360
Heavy Atom Count:21
Complexity:360

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CNCCC12C3=CC=CC=C3C(O2)C4=CC=C(C=C4)F

Technology Process of 3-(4-Fluorophenyl)spiro[isobenzofuran-1(3H),4'-piperidine]

There total 5 articles about 3-(4-Fluorophenyl)spiro[isobenzofuran-1(3H),4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59142-81-3
3-(4-fluoro-phenyl)-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-carboxylic acid ethyl ester

: 59142-97-1
3-(4-fluoro-phenyl)-3H-spiro[isobenzofuran-1,4'-piperidine]

Guidance literature:: With sodium hydroxide; In ethanol; for 18h; Heating;
DOI:10.1021/jm00233a012

Reference yield:

: 60081-24-5
1'-benzyl-3-(4-fluoro-phenyl)-3H-spiro[isobenzofuran-1,4'-piperidine]

: 59142-97-1
3-(4-fluoro-phenyl)-3H-spiro[isobenzofuran-1,4'-piperidine]

Guidance literature:: Multi-step reaction with 2 steps

1: benzene / 18 h / Heating

2: aq. NaOH / ethanol / 18 h / Heating

With sodium hydroxide; In ethanol; benzene;
DOI:10.1021/jm00233a012

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 59142-97-1
3-(4-fluoro-phenyl)-3H-spiro[isobenzofuran-1,4'-piperidine]

Guidance literature:: Multi-step reaction with 3 steps

1: (i) nBuLi, THF, hexane, (ii) /BRN= 128556/, (iii) aq. HCl, AcOH

2: benzene / 18 h / Heating

3: aq. NaOH / ethanol / 18 h / Heating

With sodium hydroxide; In ethanol; benzene;
DOI:10.1021/jm00233a012