[3-((R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-5-[4-(5-trifluoromethyl-furan-2-ylmethyl)-piperazin-1-yl]-3,6-dihydro-2H-pyrimidin-1-yl}-1-phenyl-ethylamino)-propyl]-phosphonic acid monoethyl ester

Base Information

Chemical Name:[3-((R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-5-[4-(5-trifluoromethyl-furan-2-ylmethyl)-piperazin-1-yl]-3,6-dihydro-2H-pyrimidin-1-yl}-1-phenyl-ethylamino)-propyl]-phosphonic acid monoethyl ester
CAS No.:1308379-12-5
Molecular Formula:C₃₆H₄₁F₇N₅O₆P
Molecular Weight:803.714
Hs Code.:

[3-((R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-5-[4-(5-trifluoromethyl-furan-2-ylmethyl)-piperazin-1-yl]-3,6-dihydro-2H-pyrimidin-1-yl}-1-phenyl-ethylamino)-propyl]-phosphonic acid monoethyl ester

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Chemical Property of [3-((R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-5-[4-(5-trifluoromethyl-furan-2-ylmethyl)-piperazin-1-yl]-3,6-dihydro-2H-pyrimidin-1-yl}-1-phenyl-ethylamino)-propyl]-phosphonic acid monoethyl ester

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Technology Process of [3-((R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-5-[4-(5-trifluoromethyl-furan-2-ylmethyl)-piperazin-1-yl]-3,6-dihydro-2H-pyrimidin-1-yl}-1-phenyl-ethylamino)-propyl]-phosphonic acid monoethyl ester

There total 7 articles about [3-((R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-5-[4-(5-trifluoromethyl-furan-2-ylmethyl)-piperazin-1-yl]-3,6-dihydro-2H-pyrimidin-1-yl}-1-phenyl-ethylamino)-propyl]-phosphonic acid monoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₈H₄₅F₇N₅O₆P

: 1308379-12-5
[3-((R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-5-[4-(5-trifluoromethyl-furan-2-ylmethyl)-piperazin-1-yl]-3,6-dihydro-2H-pyrimidin-1-yl}-1-phenyl-ethylamino)-propyl]-phosphonic acid monoethyl ester

Guidance literature:: C₃₈H₄₅F₇N₅O₆P; With sodium hydroxide; In ethanol; water; at 60 ℃; for 3h;

With hydrogenchloride; In water;
DOI:10.1021/acs.jmedchem.6b01071

Reference yield:

: 1308376-62-6
(R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione

: 1308379-12-5
[3-((R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-5-[4-(5-trifluoromethyl-furan-2-ylmethyl)-piperazin-1-yl]-3,6-dihydro-2H-pyrimidin-1-yl}-1-phenyl-ethylamino)-propyl]-phosphonic acid monoethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 95 °C

2: sodium hydroxide / water; ethanol / 3 h / 60 °C

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; water; acetonitrile;
DOI:10.1021/acs.jmedchem.6b01071

Reference yield:

: 1308380-26-8
((R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-5-[4-(5-trifluoromethyl-furan-2-ylmethyl)-piperazin-1-yl]-3,6-dihydro-2H-pyrimidin-1-yl}-1-phenyl-ethyl)-carbamic acid tert-butyl ester

: 1308379-12-5
[3-((R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-5-[4-(5-trifluoromethyl-furan-2-ylmethyl)-piperazin-1-yl]-3,6-dihydro-2H-pyrimidin-1-yl}-1-phenyl-ethylamino)-propyl]-phosphonic acid monoethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 95 °C

3: sodium hydroxide / water; ethanol / 3 h / 60 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/acs.jmedchem.6b01071