2-methyl-3-phenyl-2,3-dihydrobenzo[d]isoxazole

Base Information

• Chemical Name: 2-methyl-3-phenyl-2,3-dihydrobenzo[d]isoxazole
• CAS No.: 22278-45-1
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.263
• Mol file: 22278-45-1.mol

Synonyms:

Chemical Property of 2-methyl-3-phenyl-2,3-dihydrobenzo[d]isoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-3-phenyl-2,3-dihydrobenzo[d]isoxazole

There total 8 articles about 2-methyl-3-phenyl-2,3-dihydrobenzo[d]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-3-phenylbenzo[d]isoxazol-2-ium perchlorate → 2-methyl-3-phenyl-2,3-dihydrobenzo[d]isoxazole (22278-45-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1039/c5ob01715g

Reference yield:

2-Fluorobenzaldehyde (446-52-6) → 2-methyl-3-phenyl-2,3-dihydrobenzo[d]isoxazole (22278-45-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: magnesium; iodine / tetrahydrofuran / Inert atmosphere; Reflux

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: Jones reagent / acetone / 1 h / 0 °C

3.1: sodium hydride; hydroxylamine hydrochloride / N,N-dimethyl-formamide / 0.5 h / 0 °C

4.1: 130 °C

5.1: perchloric acid / water / 20 °C

6.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C / Inert atmosphere

With sodium tetrahydroborate; Jones reagent; perchloric acid; hydroxylamine hydrochloride; iodine; sodium hydride; magnesium; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone;

DOI:10.1039/c5ob01715g

Reference yield:

bromobenzene (108-86-1,52753-63-6) → 2-methyl-3-phenyl-2,3-dihydrobenzo[d]isoxazole (22278-45-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: magnesium; iodine / tetrahydrofuran / Inert atmosphere; Reflux

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: Jones reagent / acetone / 1 h / 0 °C

3.1: sodium hydride; hydroxylamine hydrochloride / N,N-dimethyl-formamide / 0.5 h / 0 °C

4.1: 130 °C

5.1: perchloric acid / water / 20 °C

6.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C / Inert atmosphere

With sodium tetrahydroborate; Jones reagent; perchloric acid; hydroxylamine hydrochloride; iodine; sodium hydride; magnesium; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone;

DOI:10.1039/c5ob01715g

upstream raw materials:

benzenedizolium-2-carboxylate

N-methyl-α-phenylnitrone

2-Fluorobenzaldehyde

bromobenzene

Refernces