Technology Process of Glycine,
D-2-[3-[4-[2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-methoxy-3-oxoprop
yl]phenoxy]phenyl]-N-[N-[(phenylmethoxy)carbonyl]glycyl]-, ethyl ester,
(R)-
There total 10 articles about Glycine,
D-2-[3-[4-[2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-methoxy-3-oxoprop
yl]phenoxy]phenyl]-N-[N-[(phenylmethoxy)carbonyl]glycyl]-, ethyl ester,
(R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: Et3N / tetrahydrofuran / a) -78 deg C, 10 min, b) 0 deg C, 30 min
2: 1) n-BuLi / 1) hexane, THF, -78 deg C, 2) a) -78 deg C, 15 min, b) up to room temp., 45 min
3: 1) KHMDS, 2) trisyl azide / 1) THF, -78 deg C, 30 min, 2) THF, -78 deg C, 2 min
4: aq. LiOH, 30percent H2O2 / tetrahydrofuran; H2O / 1 h / 0 °C
5: diethyl ether
6: 67 percent / H2 / 10percent Pd/C / ethyl acetate / 3 h / 760 Torr / Ambient temperature
With
lithium hydroxide; n-butyllithium; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; water; ethyl acetate;
DOI:10.1021/jo00032a028
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 67 percent / H2 / 10percent Pd/C / ethyl acetate / 3 h / 760 Torr / Ambient temperature
With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
DOI:10.1021/jo00032a028
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1) n-BuLi / 1) hexane, THF, -78 deg C, 2) a) -78 deg C, 15 min, b) up to room temp., 45 min
2: 1) KHMDS, 2) trisyl azide / 1) THF, -78 deg C, 30 min, 2) THF, -78 deg C, 2 min
3: aq. LiOH, 30percent H2O2 / tetrahydrofuran; H2O / 1 h / 0 °C
4: diethyl ether
5: 67 percent / H2 / 10percent Pd/C / ethyl acetate / 3 h / 760 Torr / Ambient temperature
With
lithium hydroxide; n-butyllithium; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; water; ethyl acetate;
DOI:10.1021/jo00032a028
