N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-{[1-(methoxycarbonyl)piperidin-4-yl](methyl)amino}-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide

Base Information

• Chemical Name: N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-{[1-(methoxycarbonyl)piperidin-4-yl](methyl)amino}-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide
• CAS No.: 1286264-65-0
• Molecular Formula: C₃₀H₃₉Cl₂N₅O₅
• Molecular Weight: 620.576
• Mol file: 1286264-65-0.mol

Synonyms:

Chemical Property of N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-{[1-(methoxycarbonyl)piperidin-4-yl](methyl)amino}-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-{[1-(methoxycarbonyl)piperidin-4-yl](methyl)amino}-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide

There total 10 articles about N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-{[1-(methoxycarbonyl)piperidin-4-yl](methyl)amino}-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[5-chloro-2-(4-chlorophenoxy)phenyl]iminodiacetic acid diethyl ester → N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-{2-{[1-(methoxycarbonyl)piperidin-4-yl](methyl)amino}-2-oxoethyl}-N1-(2-pyrrolidin-1-ylethyl)glycinamide (1286264-65-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide; water / methanol; tetrahydrofuran / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

3: 0 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 0 - 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.06.008

Reference yield:

C16H11Cl2NO4 → N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-{2-{[1-(methoxycarbonyl)piperidin-4-yl](methyl)amino}-2-oxoethyl}-N1-(2-pyrrolidin-1-ylethyl)glycinamide (1286264-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 0 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

DOI:10.1016/j.bmcl.2014.06.008

Reference yield:

N-[5-chloro-2-(4-chlorophenoxy)phenyl]iminodiacetic acid → N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-{2-{[1-(methoxycarbonyl)piperidin-4-yl](methyl)amino}-2-oxoethyl}-N1-(2-pyrrolidin-1-ylethyl)glycinamide (1286264-65-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2: 0 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.06.008

upstream raw materials:

1-(2-aminoethyl)pyrrolidine

2,5-dichloronitrobenzene

4-chloro-phenol

4-chloro-1-(4-chlorophenoxy)-2-nitrobenzene