1-Hexadecanol, 16-[(tetrahydro-2H-pyran-2-yl)oxy]-

Base Information

Chemical Name:1-Hexadecanol, 16-[(tetrahydro-2H-pyran-2-yl)oxy]-
CAS No.:139386-65-5
Molecular Formula:C21H42O3
Molecular Weight:342.563
Hs Code.:
DSSTox Substance ID:DTXSID90454053
Nikkaji Number:J451.365G
Mol file:139386-65-5.mol

Synonyms:1-Hexadecanol, 16-[(tetrahydro-2H-pyran-2-yl)oxy]-;139386-65-5;DTXSID90454053;16-Hydroxyhexadecyl[(3,4,5,6-tetrahydro-2H-pyran)-2-yl] ether

Suppliers and Price of 1-Hexadecanol, 16-[(tetrahydro-2H-pyran-2-yl)oxy]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Hexadecanol, 16-[(tetrahydro-2H-pyran-2-yl)oxy]-

Chemical Property:

XLogP3:7.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:17
Exact Mass:342.31339520
Heavy Atom Count:24
Complexity:245

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCOC(C1)OCCCCCCCCCCCCCCCCO

Technology Process of 1-Hexadecanol, 16-[(tetrahydro-2H-pyran-2-yl)oxy]-

There total 1 articles about 1-Hexadecanol, 16-[(tetrahydro-2H-pyran-2-yl)oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59101-28-9
16-bromohexadecan-1-ol

: 139386-65-5
1-hydroxy-16-(2'-tetrahydropyranyloxy)-hexadecane

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium p-toluenesulfonate / chloroform / 3 h / Reflux; Inert atmosphere

2: N,N-dimethyl-formamide / 6 h / 90 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; pyridinium p-toluenesulfonate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/acs.orglett.5b02816

Reference yield:

: 139386-65-5
1-hydroxy-16-(2'-tetrahydropyranyloxy)-hexadecane

: 176211-31-7
1-O-benzyl-2-O-(16-hydroxyhexadecanyl)-3-O-[16-(4-methoxybenzyloxy)hexadecanyl]-sn-glycerol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 97 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 - 20 °C

2.1: NaH / dimethylsulfoxide / 0.5 h / 20 °C

2.2: 97 percent / dimethylsulfoxide / 12 h / 20 °C

3.1: 93 percent / aq. HCl / tetrahydrofuran; methanol / 11 h / 20 °C

With hydrogenchloride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; 1.1: Esterification / 2.1: Metallation / 2.2: Etherification / 3.1: Hydrolysis;
DOI:10.1246/bcsj.70.2545

Reference yield:

: 139386-65-5
1-hydroxy-16-(2'-tetrahydropyranyloxy)-hexadecane

: 176211-32-8
1-O-benzyl-2-O-[16-(4-methoxybenzyloxy)hexadecanyl]-3-O-(16-hydroxyhexadecanyl)-sn-glycerol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 97 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 - 20 °C

2.1: NaH / dimethylsulfoxide / 0.5 h / 20 °C

2.2: 97 percent / dimethylsulfoxide / 12 h / 20 °C

3.1: 98 percent / aq. HCl / tetrahydrofuran; methanol / 11 h / 20 °C

With hydrogenchloride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; 1.1: Esterification / 2.1: Metallation / 2.2: Etherification / 3.1: Hydrolysis;
DOI:10.1246/bcsj.70.2545