1-Methylethyl-((2'R,3R,Z)-2'-(<(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxycarbonyl)-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidin>-2-ylidene)acetate

Base Information

Chemical Name:1-Methylethyl-((2'R,3R,Z)-2'-(<(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxycarbonyl)-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidin>-2-ylidene)acetate
CAS No.:129376-68-7
Molecular Formula:C₄₀H₄₈N₂O₆S
Molecular Weight:684.897
Hs Code.:

1-Methylethyl-((2'R,3R,Z)-2'-(<(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxycarbonyl)-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidin>-2-ylidene)acetate

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Chemical Property of 1-Methylethyl-((2'R,3R,Z)-2'-(<(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxycarbonyl)-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidin>-2-ylidene)acetate

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Technology Process of 1-Methylethyl-((2'R,3R,Z)-2'-(<(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxycarbonyl)-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidin>-2-ylidene)acetate

There total 6 articles about 1-Methylethyl-((2'R,3R,Z)-2'-(<(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxycarbonyl)-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidin>-2-ylidene)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(E)-2-(2-Isopropoxycarbonylmethyl-1H-indol-3-yl)-ethylimino]-acetic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

: 98-59-9
p-toluenesulfonyl chloride

: 129376-68-7,129444-93-5
1-Methylethyl-((2'R,3S,Z)-2'-(<(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxycarbonyl)-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidin>-2-ylidene)acetate

: 129376-68-7,129444-93-5
1-Methylethyl-((2'R,3R,Z)-2'-(<(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxycarbonyl)-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidin>-2-ylidene)acetate

Guidance literature:: With 2,4,6-trimethyl-pyridine; In dichloromethane; at -80 - -78 ℃; for 140h; Yield given. Yields of byproduct given;
DOI:10.1002/hlca.19900730224

Reference yield:

: [(E)-2-(2-Isopropoxycarbonylmethyl-1H-indol-3-yl)-ethylimino]-acetic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

: 98-59-9
p-toluenesulfonyl chloride

: 129376-68-7,129444-93-5
1-Methylethyl-((2'R,3S,Z)-2'-(<(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxycarbonyl)-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidin>-2-ylidene)acetate

: 129376-68-7,129444-93-5
1-Methylethyl-((2'R,3R,Z)-2'-(<(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxycarbonyl)-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidin>-2-ylidene)acetate

Guidance literature:: With 2,4,6-trimethyl-pyridine; In dichloromethane; at -80 - -78 ℃; for 140h; Yield given. Yields of byproduct given;
DOI:10.1002/hlca.19900730224

Reference yield:

: 122419-63-0
isopropyl 3-(2-aminoethyl)-1H-indole-2-acetate

: 129376-68-7,129444-93-5
1-Methylethyl-((2'R,3S,Z)-2'-(<(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxycarbonyl)-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidin>-2-ylidene)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: molecular sieves / CH₂Cl₂ / 18 h / Ambient temperature

2: 2,4,6-Trimethylpyridine / CH₂Cl₂ / 140 h / -80 - -78 °C

With 2,4,6-trimethyl-pyridine; molecular sieve; In dichloromethane;
DOI:10.1002/hlca.19900730224