Technology Process of (2R,3S)-3-(dibenzylamino)-2-[(4-methoxybenzyl)oxy]butanoic acid
There total 8 articles about (2R,3S)-3-(dibenzylamino)-2-[(4-methoxybenzyl)oxy]butanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene;
In
water; tert-butyl alcohol;
at 20 ℃;
for 3h;
optical yield given as %de;
Inert atmosphere;
DOI:10.1055/s-0031-1289746
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / toluene / 20 h / Reflux; Inert atmosphere
2.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C / Inert atmosphere
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 - 0 °C / Inert atmosphere
3.2: 4 h / 0 °C / Inert atmosphere
4.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 3 h / 20 °C / Inert atmosphere
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide;
In
dichloromethane; water; toluene; tert-butyl alcohol;
3.1: Swern oxidation / 3.2: Swern oxidation / 4.1: Pinnick oxidation;
DOI:10.1055/s-0031-1289746
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 - 0 °C / Inert atmosphere
1.2: 4 h / 0 °C / Inert atmosphere
2.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 3 h / 20 °C / Inert atmosphere
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane; water; tert-butyl alcohol;
1.1: Swern oxidation / 1.2: Swern oxidation / 2.1: Pinnick oxidation;
DOI:10.1055/s-0031-1289746
